Insulinotropic activity in 16.7 mM glucose-stimulated Sprague-Dawley rat islets of langerhans assessed as insulin release per 20 islets at 10 nM treated for 2 hrs after glucose challenge measured after 2 hrs of glucose stimulation by EIA (Rvb = 58.32 +/- 6.35 ng/mL)
Insulinotropic activity in 2.2 mM glucose-stimulated Sprague-Dawley rat islets of langerhans assessed as insulin release per 20 islets at 10 nM treated for 2 hrs after glucose challenge measured after 2 hrs of glucose stimulation by EIA
Antidiabetic activity in overnight fasted db/db mouse assessed as increase in glucose tolerance at 10 nmol/kg, sc administered 30 mins prior to glucose challenge measured after 120 mins by IPGTT
Antidiabetic activity in overnight fasted db/db mouse assessed as blood glucose level at 10 nmol/kg, sc administered 30 mins prior to glucose challenge measured after 30 mins by IPGTT (Rvb = 20.96 +/- 2.20 nM)
Antidiabetic activity in overnight fasted db/db mouse assessed as blood glucose level at 10 nmol/kg, sc administered 30 mins prior to glucose challenge measured after 120 mins by IPGTT (Rvb = 13.14 +/- 0.90 nM)
Antidiabetic activity in overnight fasted db/db mouse assessed as decrease in glucose AUC at 10 nmol/kg, sc administered 30 mins prior to glucose challenge measured after 120 mins by IPGTT