Antitumor activity against rat AH-130 cells allografted in Donryu rat assessed as tumor weight at 90 mg/kg, ip administered daily for 7 days starting 24 hrs after tumor inoculation measured on 10th day post-tumor inoculation (Rvb = 4.73 +/- 1.19 gms)
Antitumor activity against rat AH-130 cells allografted in Donryu rat assessed as inhibition of tumor growth at 90 mg/kg, ip administered daily for 7 days starting 24 hrs after tumor inoculation measured on 10th day post-tumor inoculation
Antitumor activity against rat Yoshida cells allografted in Donryu rat assessed as tumor weight at 90 mg/kg, ip administered daily for 7 days starting 24 hrs after tumor inoculation measured on 10th day post-tumor inoculation (Rvb = 3.65 +/- 0.60 gms)
Antitumor activity against rat Yoshida cells allografted in Donryu rat assessed as inhibition of tumor growth at 90 mg/kg, ip administered daily for 7 days starting 24 hrs after tumor inoculation measured on 10th day post-tumor inoculation
Toxicity in Donryu rat allografted with rat AH-130 cells assessed as body weight at 90 mg/kg, ip administered daily for 7 days starting 24 hrs after tumor inoculation measured on 10th day post-tumor inoculation (Rvb = 64.1 gms)
Toxicity in Donryu rat allografted with rat Yoshida cells assessed as body weight at 90 mg/kg, ip administered daily for 7 days starting 24 hrs after tumor inoculation measured on 10th day post-tumor inoculation (Rvb = 53 gms)
Drug metabolism in mouse liver microsomes assessed as fluorouracil release by measuring antibacterial activity against Staphylococcus aureus 209P at 200 ug after 4 hrs by thin layer cup method
Drug metabolism in mouse liver microsomes assessed as fluorouracil release by measuring antibacterial activity against Staphylococcus aureus 209P at 200 ug after 4 hrs by thin layer cup method in presence of NADPH
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory)