# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA901540 | B | Inhibition of Clostridium botulinum A recombinant light chain protease LC/A by FRET assay | Clostridium botulinum | 18 | ALA1138256 | assay format | Scientific Literature | |
2. | ALA925837 | T | Toxicity against mouse Neuro2a cells at =>5 uM | Mus musculus | 1 | ALA1147064 | cell-based format | Scientific Literature | |
3. | ALA925839 | F | Inhibition of Clostridium botulinum recombinant BoNT/A light chain-mediated toxicity in iv dosed CD1 mouse assessed as survival | Mus musculus | 1 | ALA1147064 | organism-based format | Scientific Literature | |
4. | ALA961806 | B | Inhibition of Clostridium botulinum recombinant Bont/A light chain expressed in Escherichia coli BL21 GOLD | Clostridium botulinum | 14 | ALA1153454 | assay format | Scientific Literature | |
5. | ALA961808 | B | Inhibition of Clostridium botulinum recombinant Bont/A light chain | Clostridium botulinum | 2 | ALA1153454 | single protein format | Scientific Literature | |
6. | ALA1047164 | B | Inhibition of Clostridium botulinum neurotoxin A light chain by FRET-based assay | Clostridium botulinum | 1 | ALA1156013 | single protein format | Scientific Literature | |
7. | ALA1047165 | B | Inhibition of Clostridium botulinum neurotoxin A light chain by HPLC-based assay | Clostridium botulinum | 5 | ALA1156013 | single protein format | Scientific Literature | |
8. | ALA1069850 | B | Inhibition of Clostridium botulinum BoNT/A | Clostridium botulinum | 3 | ALA1153125 | single protein format | Scientific Literature | |
9. | ALA1071240 | B | Inhibition of Clostridium botulinum BoNT/A expressed in rat spinal cord neuron assessed as decrease in SNAP25 cleavage up to 600 uM | Clostridium botulinum | 2 | ALA1153125 | assay format | Scientific Literature | |
10. | ALA1067457 | B | Inhibition of Clostridium botulinum toxin BoNT/A light chain | Clostridium botulinum | 3 | ALA1157595 | single protein format | Scientific Literature | |
11. | ALA2033254 | B | Inhibition of clostridium botulinum Botulinum neurotoxin type A using SNAPide as substrate by FRET analysis | Clostridium botulinum | 44 | ALA2029297 | single protein format | Scientific Literature | |
12. | ALA2329358 | B | Ratio of IC50 for Clostridium botulinum full length BoNT/A light chain (1-448) to IC50 for Clostridium botulinum truncated BoNT/A light chain (1-425) | Clostridium botulinum | 2 | ALA2321774 | single protein format | Scientific Literature | |
13. | ALA2329360 | B | Competitive inhibition of Clostridium botulinum truncated BoNT/A light chain (1-425) using truncated SNAP 25 (141-206) peptide as substrate by LC/MS analysis | Clostridium botulinum | 3 | ALA2321774 | single protein format | Scientific Literature | |
14. | ALA2329362 | B | Competitive inhibition of Clostridium botulinum full length BoNT/A light chain (1-448) using truncated SNAP 25 (141-206) peptide as substrate by LC/MS analysis | Clostridium botulinum | 3 | ALA2321774 | single protein format | Scientific Literature | |
15. | ALA2343854 | B | Competitive inhibition of Clostridium botulinum BoNT/A Hall A hyper protease light chain (1-425aa) using SNAP-66mer (141-206aa) as substrate by FRET assay | Clostridium botulinum | 8 | ALA2331385 | single protein format | Scientific Literature | |
16. | ALA2439707 | B | Binding affinity to human holo-transferrin assessed as pseudo-first-order rate constant measured as removal of ferric ion at 1 mM measured for 1 hr by UV-vis spectrophotometric analysis | Homo sapiens | 10 | ALA2434956 | single protein format | Scientific Literature | |
17. | ALA2439708 | B | Inhibition of TPCK-treated trypsin (unknown origin) at 10 uM preincubated for 10 mins prior to substrate addition measured for 30 mins by spectrophotometric analysis | Homo sapiens | 10 | ALA2434956 | protein format | Scientific Literature | |
18. | ALA2439709 | B | Inhibition of mushroom tyrosinase assessed as L-DOPA conversion to melanin at 10 uM preincubated for 10 mins prior to substrate addition measured after 10 mins by spectrophotometric analysis | Agaricus bisporus | 10 | ALA2434956 | single protein format | Scientific Literature | |
19. | ALA2439711 | B | Inhibition of HDAC2 (unknown origin)-mediated deacetylation at 10 uM preincubated for 5 mins prior to substrate addition measured after 30 mins by fluorescence assay | Homo sapiens | 11 | ALA2434956 | single protein format | Scientific Literature | |
20. | ALA2439712 | B | Inhibition of human carbonic anhydrase 2 assessed as p-nitrophenyl acetate conversion to p-nitrophenolate anion at 10 uM preincubated for 10 mins prior to substrate addition measured for 20 mins by spectrophotometric analysis relative to control | Homo sapiens | 10 | ALA2434956 | single protein format | Scientific Literature |