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# Aladdin ID Assay Type Description Organism Compounds Reference BAO Format Source 1. ALA1040691 Functional NOVARTIS: Inhibition of Plasmodium falciparum 3D7 (drug-susceptible) proliferation in erythrocyte-based infection assay Plasmodium falciparum 5,614 ALA1156829 organism-based format Novartis Malaria Screening 2. ALA1040692 Functional NOVARTIS: Inhibition of Plasmodium falciparum W2 (drug-resistant) proliferation in erythrocyte-based infection assay Plasmodium falciparum 5,614 ALA1156829 organism-based format Novartis Malaria Screening 3. ALA1040693 Toxicity NOVARTIS: Cytotoxicity against human hepatocellular carcinoma cell line (Huh7) Homo sapiens 5,614 ALA1156829 cell-based format Novartis Malaria Screening 4. ALA1040694 Functional NOVARTIS: Inhibition Frequency Index (IFI) - the number of HTS assays where a compound showed > 50% inhibition/induction, expressed as a percentage of the number of assays in which the compound was tested. 5,614 ALA1156829 assay format Novartis Malaria Screening 5. ALA1046172 Binding Displacement of [3H]adenine from adenine 1 receptor in rat brain cortical membrane by liquid scintillation counting Rattus norvegicus 61 ALA1156038 cell membrane format Scientific Literature 6. ALA1046176 Binding Displacement of [3H]adenine from adenine 1 receptor in HEK293 cells by liquid scintillation counting Homo sapiens 25 ALA1156038 cell-based format Scientific Literature 7. ALA1046178 Binding Selectivity ratio of Ki for adenine 1 receptor in HEK293 cells to Ki for adenine 1 receptor in rat brain cortical membrane 23 ALA1156038 cell-based format Scientific Literature 8. ALA758629 Binding Inhibition of Phosphatidylinositol 4-kinase at the ATP binding site at 500 uM 20 ALA1124860 protein format Scientific Literature 9. ALA898384 Functional Antimalarial activity against drug-sensitive Plasmodium falciparum 3D7 after 24 hrs Plasmodium falciparum 26 ALA1149611 organism-based format Scientific Literature 10. ALA898385 Functional Antimalarial activity against chloroquine,pyrimethamine-resistant Plasmodium falciparum K1 after 24 hrs Plasmodium falciparum 20 ALA1149611 organism-based format Scientific Literature 11. ALA898386 Functional Antimalarial activity against chloroquine, pyrimethamine and cycloguanil-resistant Plasmodium falciparum VS1 after 24 hrs Plasmodium falciparum 26 ALA1149611 organism-based format Scientific Literature 12. ALA898387 Functional Cytotoxicity against human KB cells Homo sapiens 27 ALA1149611 cell-based format Scientific Literature 13. ALA898388 Functional Selectivity index, ratio of CC50 for human KB cells to IC50 for Plasmodium falciparum 3D7 26 ALA1149611 cell-based format Scientific Literature 14. ALA898389 Functional Selectivity index, ratio of CC50 for human KB cells to IC50 for Plasmodium falciparum K1 20 ALA1149611 cell-based format Scientific Literature 15. ALA898390 Functional Selectivity index, ratio of CC50 for human KB cells to IC50 for Plasmodium falciparum VS1 26 ALA1149611 cell-based format Scientific Literature