# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA980013 | ADME | Half life in Sprague-Dawley rat at 4 umol/mL/kg, iv | Rattus norvegicus | 5 | ALA1140037 | organism-based format | Scientific Literature | |
2. | ALA980015 | ADME | Plasma clearance in Sprague-Dawley rat at 4 umol/mL/kg, iv | Rattus norvegicus | 5 | ALA1140037 | organism-based format | Scientific Literature | |
3. | ALA980017 | ADME | Volume of distribution at steady state in Sprague-Dawley rat at 4 umol/mL/kg, iv | Rattus norvegicus | 5 | ALA1140037 | organism-based format | Scientific Literature | |
4. | ALA980019 | ADME | Bioavailability in Sprague-Dawley rat at 10 umol/5 mL/kg, po | Rattus norvegicus | 5 | ALA1140037 | organism-based format | Scientific Literature | |
5. | ALA980875 | Functional | Antibone resorptive activity in Sprague-Dawley rat assessed as inhibition of cathepsin K-mediated C-terminal telopeptidase of type 1 collagen degradation at 100 mg/kg/day, po for 11 days measured on 24 hrs after final administration by RatLaps ELISA | Rattus norvegicus | 7 | ALA1140037 | organism-based format | Scientific Literature | |
6. | ALA980876 | ADME | Drug level in Sprague-Dawley rat serum at 100 mg/kg/day, po for 11 days measured on 25 hrs after final administration | Rattus norvegicus | 7 | ALA1140037 | organism-based format | Scientific Literature | |
7. | ALA980877 | ADME | Drug level in Sprague-Dawley rat bone marrow at 100 mg/kg/day, po for 11 days measured on 25 hrs after final administration | Rattus norvegicus | 7 | ALA1140037 | organism-based format | Scientific Literature | |
8. | ALA980878 | ADME | Ratio of drug level in bone marrow to serum in po dosed Sprague-Dawley rat | Rattus norvegicus | 7 | ALA1140037 | organism-based format | Scientific Literature | |
9. | ALA980886 | Binding | Inhibition of rat recombinant cathepsin K expressed in Sf21 cells by fluorescence assay | Rattus norvegicus | 8 | ALA1140037 | cell-based format | Scientific Literature | |
10. | ALA924502 | Binding | Inhibition of cathepsin K by fluorescence assay | 33 | ALA1140545 | single protein format | Scientific Literature | ||
11. | ALA924503 | Binding | Inhibition of cathepsin L by fluorescence assay | Homo sapiens | 33 | ALA1140545 | assay format | Scientific Literature | |
12. | ALA924504 | Binding | Inhibition of cathepsin S by fluorescence assay | 33 | ALA1140545 | single protein format | Scientific Literature |