Antibone resorptive activity in Sprague-Dawley rat assessed as inhibition of cathepsin K-mediated C-terminal telopeptidase of type 1 collagen degradation at 100 mg/kg/day, po for 11 days measured on 24 hrs after final administration by RatLaps ELISA
Antibone resorptive activity in cynomolgus monkey assessed as reduction of C-terminal telopeptidase of type 1 collagen degradation at 2 mg/kg/day, po measured before 8 hrs after first administration by CrossLaps ELISA
Antibone resorptive activity in cynomolgus monkey assessed as reduction of C-terminal telopeptidase of type 1 collagen degradation at 2 mg/kg/day, po measured after 24 hrs after first administration by CrossLaps ELISA
Antibone resorptive activity in cynomolgus monkey assessed as reduction of C-terminal telopeptidase of type 1 collagen degradation at 2 mg/kg/day, po measured before 8 hrs after 7 days of administration by CrossLaps ELISA
Antibone resorptive activity in cynomolgus monkey assessed as reduction of C-terminal telopeptidase of type 1 collagen degradation at 2 mg/kg/day, po measured after 8 hrs after 7 days of administration by CrossLaps ELISA
Antibone resorptive activity in cynomolgus monkey assessed as reduction of C-terminal telopeptidase of type 1 collagen degradation at 2 mg/kg/day, po measured before 8 hrs after 14 days of administration by CrossLaps ELISA
Antibone resorptive activity in cynomolgus monkey assessed as reduction of cathepsin K-mediated C-terminal telopeptidase of type 1 collagen degradation at 2 mg/kg/day, po measured after 8 hrs after 14 days of administration by CrossLaps ELISA