# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA926728 | B | Inhibition of Trypanosoma brucei cathepsin B-like cysteine protease | Trypanosoma brucei | 56 | single protein format | Scientific Literature | ||
2. | ALA926729 | F | Antitrypanosomal activity against Trypanosoma brucei | Trypanosoma brucei | 58 | organism-based format | Scientific Literature | ||
3. | ALA926730 | B | Inhibition of human liver cathepsin L | Homo sapiens | 56 | assay format | Scientific Literature | ||
4. | ALA926731 | B | Inhibition of human liver cathepsin B | Homo sapiens | 58 | assay format | Scientific Literature | ||
5. | ALA1291582 | T | Toxicity in human erythrocyte assessed as hemolysis at 10 uM after 5 hrs | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
6. | ALA1291589 | A | Half life in CD1 mouse liver microsomes by UPLC-MS analysis | Mus musculus | 6 | microsome format | Scientific Literature | ||
7. | ALA1291590 | A | Half life in CD1 mouse plasma by UPLC-MS analysis | Mus musculus | 6 | cell-free format | Scientific Literature | ||
8. | ALA1291591 | A | Permeability of the compound assessed as ratio of compound in acceptor chamber to amount of compound in donor chamber at pH 3 by PAMPA assay | 3 | assay format | Scientific Literature | |||
9. | ALA1291593 | A | Permeability of the compound assessed as ratio of compound in acceptor chamber to amount of compound in donor chamber at pH 7.4 by PAMPA assay | 3 | assay format | Scientific Literature | |||
10. | ALA1291594 | P | Aqueous solubility of compound in deionized water | 6 | small-molecule physicochemical format | Scientific Literature | |||
11. | ALA1291596 | F | Antitrypanosomal activity against Trypanosoma brucei after 48 hrs | Trypanosoma brucei | 7 | organism-based format | Scientific Literature | ||
12. | ALA1291668 | A | Stability of the compound in po dosed mouse blood | Mus musculus | 3 | organism-based format | Scientific Literature | ||
13. | ALA1291681 | A | Therapeutic index, ratio of EC50 for human cells to EC50 for Trypanosoma brucei | 6 | assay format | Scientific Literature |