| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA928888 | B | Displacement of europium labeled-human IL8 from human cloned CXCR2 expressed in Sf9 membrane with Galphai3-beta-1-gamma-2 by DELFIA binding assay | Homo sapiens | 27 | cell-based format | Scientific Literature | ||
| 2. | ALA928889 | F | Antagonist activity at human cloned CXCR2 by calcium flux FLIPR assay | Homo sapiens | 6 | assay format | Scientific Literature | ||
| 3. | ALA928890 | F | Antagonist activity at rabbit CXCR2 by neutrophil chemotaxis assay | Oryctolagus cuniculus | 6 | assay format | Scientific Literature | ||
| 4. | ALA3301363 | P | ASTRAZENECA: Octan-1-ol/water (pH7.4) distribution coefficent measured by a shake flask method described in J. Biomol. Screen. 2011, 16, 348-355. Experimental range -1.5 to 4.5 | 4,197 | small-molecule physicochemical format | AstraZeneca Deposited Data | |||
| 5. | ALA3301365 | A | ASTRAZENECA: % bound to plasma by equilibrium dialysis. Compound is incubated with whole human plasma at 37C for >5hrs. Method described in B. Testa et al (Eds.), Pharmacokinetic Profiling in Drug Research: Biological, Physicochemical, and Computational Strategies, Wiley-VCH, Weinheim, 2006, pp.119-141. Experimental range 10% to 99.95% bound. | Homo sapiens | 1,614 | cell-free format | AstraZeneca Deposited Data | ||
| 6. | ALA3301370 | A | ASTRAZENECA: Intrinsic clearance measured in human liver microsomes following incubation at 37C. Experimental range <3 to >150 microL/min/mg. Rapid Commun. Mass Spectrom. 2010, 24, 1730-1736. | Homo sapiens | 1,102 | microsome format | AstraZeneca Deposited Data | ||
| 7. | ALA3301371 | A | ASTRAZENECA: Intrinsic clearance measured in rat hepatocytes following incubation at 37C. Experimental range <3 to >150 microL/min/1E6 cells. Rapid Commun. Mass Spectrom. 2010, 24, 1730-1736 | Rattus norvegicus | 837 | cell-based format | AstraZeneca Deposited Data | ||
| 8. | ALA3301375 | P | ASTRAZENECA: Most acidic pKa value (pKa A1) determined by absorption and potentiometric titration using standard methodology from Sirius Analytical. Experimental range Acids: <= 11. | 221 | small-molecule physicochemical format | AstraZeneca Deposited Data |
The page will load shortly, Thanks for your patience!