| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA935677 | A | Clearance in cynomolgus monkey at 1 to 2 mg/kg, iv | Macaca fascicularis | 17 | organism-based format | Scientific Literature | ||
| 2. | ALA935678 | A | Half life in cynomolgus monkey at 1 to 2 mg/kg, iv | Macaca fascicularis | 17 | organism-based format | Scientific Literature | ||
| 3. | ALA935679 | F | Antiviral activity against HIV1 3B infected in human PBMCs by reverse transcriptase assay | Human immunodeficiency virus 1 | 19 | organism-based format | Scientific Literature | ||
| 4. | ALA935680 | F | Antiviral activity against HIV1 098 isolate infected in human PBMCs by reverse transcriptase assay | Human immunodeficiency virus 1 | 19 | organism-based format | Scientific Literature | ||
| 5. | ALA935681 | F | Antiviral activity against HIV1 098-T20 isolate infected in human PBMCs by reverse transcriptase assay | Human immunodeficiency virus 1 | 19 | organism-based format | Scientific Literature | ||
| 6. | ALA935682 | F | Antiviral activity against HIV1 098-T1249 isolate infected in human PBMCs by reverse transcriptase assay | Human immunodeficiency virus 1 | 19 | organism-based format | Scientific Literature | ||
| 7. | ALA935683 | F | Antiviral activity against HIV1 098-T651 isolate infected in human PBMCs by reverse transcriptase assay | Human immunodeficiency virus 1 | 19 | organism-based format | Scientific Literature | ||
| 8. | ALA935684 | B | Binding affinity to HIV1 gp41 heptad repeat 1 region assessed as thermal stability of HR1/HR2 peptide bundle complex at 10 uM in presence of 8M urea | Human immunodeficiency virus 1 | 17 | assay format | Scientific Literature | ||
| 9. | ALA3602692 | P | Thermostability of the compound in PBS assessed as melting temperature at 20 uM by CD spectroscopic analysis | 3 | small-molecule physicochemical format | Scientific Literature | |||
| 10. | ALA3602693 | B | Binding affinity to HIV-1 HXB2 gp41 N-terminal heptad repeat assessed as thermostability of protein-compound complex at 10 uM after 30 mins by CD spectroscopic analysis | Human immunodeficiency virus 1 | 3 | single protein format | Scientific Literature | ||
| 11. | ALA3602694 | B | Binding affinity to HIV-1 HXB2 gp41 N-terminal heptad repeat assessed as 6-helix bundle formation at 100 uM by ITC analysis | Human immunodeficiency virus 1 | 2 | single protein format | Scientific Literature | ||
| 12. | ALA3602695 | B | Inhibition of HIV-1 HXB2 gp41 N-terminal heptad repeat-mediated fusion between infected HL2/3 cells to target TZM-bl cells after 6 hrs by luciferase reporter gene assay | Human immunodeficiency virus 1 | 11 | cell-based format | Scientific Literature | ||
| 13. | ALA3602696 | F | Antiviral activity against HIV1 NL4-3 pseudovirus infected in human TZM-bl cells assessed as inhibition of viral entry into cells after 48 hrs by single-cycle infection assay | Human immunodeficiency virus 1 | 11 | organism-based format | Scientific Literature | ||
| 14. | ALA3602697 | F | Antiviral activity against wild type HIV1 NL4-3 infected in human TZM-bl cells assessed as inhibition of viral replication after 2 days by luciferase reporter gene assay | Human immunodeficiency virus 1 | 9 | organism-based format | Scientific Literature | ||
| 15. | ALA3602698 | F | Antiviral activity against HIV-1 ZM214M.15 pseudovirus infected in human TZM-bl cells assessed as inhibition of viral entry into cells after 48 hrs by single-cycle infection assay | Human immunodeficiency virus 1 | 3 | organism-based format | Scientific Literature | ||
| 16. | ALA3602699 | F | Antiviral activity against HIV-1 SF162 pseudovirus infected in human TZM-bl cells assessed as inhibition of viral entry into cells after 48 hrs by single-cycle infection assay | Human immunodeficiency virus 1 | 3 | organism-based format | Scientific Literature | ||
| 17. | ALA3602700 | F | Antiviral activity against HIV-1 SC42261.8 pseudovirus infected in human TZM-bl cells assessed as inhibition of viral entry into cells after 48 hrs by single-cycle infection assay | Human immunodeficiency virus 1 | 3 | organism-based format | Scientific Literature | ||
| 18. | ALA3602701 | B | Binding affinity to HIV-1 HXB2 gp41 N-terminal heptad repeat assessed as inhibition of 6-helix bundle formation after 30 mins by ELISA | Human immunodeficiency virus 1 | 2 | single protein format | Scientific Literature | ||
| 19. | ALA3602702 | F | Antiviral activity against wild type HIV1 NL4-3 infected in human TZM-bl cells assessed as inhibition of viral entry into cells after 48 hrs by single-cycle infection assay | Human immunodeficiency virus 1 | 3 | organism-based format | Scientific Literature | ||
| 20. | ALA3602703 | F | Antiviral activity against ENF-resistant HIV1 NL4-3 harboring gp41 N-terminal heptad repeat D36G mutant infected in human TZM-bl cells assessed as inhibition of viral entry into cells after 48 hrs by single-cycle infection assay | Human immunodeficiency virus 1 | 3 | organism-based format | Scientific Literature |
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