| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3562002 | Functional | PubChem BioAssay. Immunotoxin (HA22) sensitization/mitigation study. Vehicle arm (PBS). (Class of assay: confirmatory) | 370 | ALA1201862 | assay format | PubChem BioAssays | ||
| 2. | ALA3562018 | Functional | PubChem BioAssay. Immunotoxin (SS1P) sensitization/mitigation study - treatment arm. (Class of assay: confirmatory) | 401 | ALA1201862 | assay format | PubChem BioAssays | ||
| 3. | ALA3562034 | Functional | PubChem BioAssay. Immunotoxin (SS1P) sensitization/mitigation study. Vehicle arm (DMEM). (Class of assay: confirmatory) | 344 | ALA1201862 | assay format | PubChem BioAssays | ||
| 4. | ALA3562067 | Functional | PubChem BioAssay. Immunotoxin (HA22) sensitization/mitigation study - treatment arm (low dose). (Class of assay: confirmatory) | 407 | ALA1201862 | organism-based format | PubChem BioAssays | ||
| 5. | ALA3606693 | Binding | Inhibition of C-flagged recombinant HDAC1 (unknown origin) pre-incubated for 1 hr before substrate addition by homogeneous fluorogenic HDAC assay | Homo sapiens | 17 | ALA3603817 | single protein format | Scientific Literature | |
| 6. | ALA3606695 | Binding | Inhibition of His-tagged recombinant HDAC2 (1 to 488 residues) (unknown origin) pre-incubated for 3 hrs before substrate addition by homogeneous fluorogenic HDAC assay | Homo sapiens | 21 | ALA3603817 | single protein format | Scientific Literature | |
| 7. | ALA3606696 | Binding | Inhibition of recombinant HDAC3/NCOR2 (unknown origin) pre-incubated for 3 hrs before substrate addition by homogeneous fluorogenic HDAC assay | Homo sapiens | 21 | ALA3603817 | protein complex format | Scientific Literature | |
| 8. | ALA3606698 | Binding | Inhibition of His-flagged recombinant HDAC6 (unknown origin) at 20 uM pre-incubated for 1 hr before substrate addition by homogeneous fluorogenic HDAC assay | Homo sapiens | 21 | ALA3603817 | single protein format | Scientific Literature | |
| 9. | ALA3606699 | Binding | Inhibition of His-flagged recombinant HDAC8 (unknown origin) expressed in Escherichia coli BL21 pre-incubated for 15 mins before substrate addition by homogeneous fluorogenic HDAC assay | Homo sapiens | 21 | ALA3603817 | assay format | Scientific Literature | |
| 10. | ALA3606709 | Physicochemical | Lipophilicity, log P of the compound | 20 | ALA3603817 | small-molecule physicochemical format | Scientific Literature | ||
| 11. | ALA3606710 | Physicochemical | Distribution coefficient, log D of the compound by HPLC method | 20 | ALA3603817 | small-molecule physicochemical format | Scientific Literature | ||
| 12. | ALA3606711 | Physicochemical | Solubility by CLND method | 20 | ALA3603817 | small-molecule physicochemical format | Scientific Literature | ||
| 13. | ALA3606712 | ADME | Permeability by artificial membrane permeability assay | 20 | ALA3603817 | assay format | Scientific Literature | ||
| 14. | ALA3606713 | ADME | Binding affinity to human serum albumin | Homo sapiens | 20 | ALA3603817 | single protein format | Scientific Literature | |
| 15. | ALA3606714 | Binding | Inhibition of HDAC3 in human U937 cells assessed as increase in histone H3 lysine-9 acetylation at 10 uM incubated for 24 hrs by Western blotting method | Homo sapiens | 4 | ALA3603817 | cell-based format | Scientific Literature | |
| 16. | ALA3606715 | Binding | Inhibition of HDAC3 in human PC3 cells assessed as increase in histone H3 lysine-9 acetylation at 10 uM incubated for 24 hrs by Western blotting method | Homo sapiens | 4 | ALA3603817 | cell-based format | Scientific Literature | |
| 17. | ALA3606790 | Binding | Inhibition of HDAC in human U937 cells assessed as reduction in cyclin E expression in at 10 uM incubated for 24 hrs by Western blotting method | Homo sapiens | 4 | ALA3603817 | cell-based format | Scientific Literature | |
| 18. | ALA3606791 | Binding | Inhibition of HDAC in human PC3 cells assessed as reduction in cyclin E expression in at 10 uM incubated for 24 hrs by Western blotting method | Homo sapiens | 4 | ALA3603817 | cell-based format | Scientific Literature | |
| 19. | ALA3606792 | Functional | Induction of apoptosis in human PC3 cells assessed as accumulation at subG1 phase at 10 uM incubated for 24 hrs by FITC/propidium iodide staining based flow cytometry (Rvb = 0.2%) | Homo sapiens | 5 | ALA3603817 | cell-based format | Scientific Literature | |
| 20. | ALA3606793 | Functional | Induction of cell cycle arrest in human PC3 cells assessed as accumulation at G0/G1 phase at 10 uM incubated for 24 hrs by FITC/propidium iodide staining based flow cytometry (Rvb = 65.5%) | Homo sapiens | 5 | ALA3603817 | cell-based format | Scientific Literature |
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