# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA1930653 | Functional | Activation of rat TAAR1 expressed in HEK293 cells assessed as accumulation of [3H]cAMP after 1 hr by competitive binding assay | Rattus norvegicus | 4 | ALA1926662 | cell-based format | Scientific Literature | |
2. | ALA947944 | Binding | Binding affinity to BACE1 by surface plasmon resonance method | 7 | ALA1142369 | single protein format | Scientific Literature | ||
3. | ALA947945 | Binding | Inhibition of BACE1 | 1 | ALA1142369 | single protein format | Scientific Literature | ||
4. | ALA3259020 | Functional | Inhibition of norepinephrine release in sc dosed mouse heart administered 60 mins before [3H]-norepinephrine challenge | Mus musculus | 6 | ALA3243928 | organism-based format | Scientific Literature | |
5. | ALA4009953 | Functional | Agonist activity at rat N-terminal FLAG-tagged TAAR1 expressed in HEK293 cells assessed as [3H]cAMP accumulation measured after 1 hr | Rattus norvegicus | 5 | ALA4007451 | cell-based format | Scientific Literature | |
6. | ALA4303810 | Functional | Antiviral activity against SARS-CoV-2 (USA-WA1/2020 strain) measured by imaging in HRCE cells at MOI 0.4 after 96 hrs (reported as hit score from 0-1 for on-disease vs off-disease activity: scores >0.6 considered hits) | Homo sapiens | 1,629 | ALA4303122 | organism-based format | SARS-CoV-2 Screening Data 2020-21 | |
7. | ALA4651403 | Functional | Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging | Chlorocebus sabaeus | 4,309 | ALA4651402 | organism-based format | IMI-CARE SARS-CoV-2 Data | |
8. | ALA4808149 | Binding | Enzymatic assay of human HDAC6 with commercial peptide substrate | Homo sapiens | 5,603 | ALA4808148 | single protein format | Fraunhofer HDAC6 | |
9. | ALA4808150 | Binding | Enzymatic assay of human HDAC6 with custom peptide substrate | Homo sapiens | 5,603 | ALA4808148 | single protein format | Fraunhofer HDAC6 | |
10. | ALA5291723 | Functional | Compound was evaluated for inhibition of human ACHE in an vitro cell free assay measured by absorbance method | 927 | ALA5291721 | assay format | Scientific Literature | ||
11. | ALA5291728 | Binding | Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting | 754 | ALA5291721 | single protein format | Scientific Literature | ||
12. | ALA5291730 | Functional | Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy | 845 | ALA5291721 | cell-based format | Scientific Literature | ||
13. | ALA5291731 | Functional | Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy | 800 | ALA5291721 | cell-based format | Scientific Literature | ||
14. | ALA5291736 | Binding | Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting | 927 | ALA5291721 | single protein format | Scientific Literature | ||
15. | ALA5291749 | Binding | Binding affinity towards human AR in an in vitro assay with cellular components measured by scintillation counting | 927 | ALA5291721 | single protein format | Scientific Literature | ||
16. | ALA5291759 | Functional | Agonist activity at human CHRM1 in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy | 842 | ALA5291721 | cell-based format | Scientific Literature | ||
17. | ALA5291761 | Functional | Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy | 812 | ALA5291721 | cell-based format | Scientific Literature | ||
18. | ALA5291766 | Binding | Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting | 927 | ALA5291721 | single protein format | Scientific Literature | ||
19. | ALA5291779 | Binding | Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting | 927 | ALA5291721 | single protein format | Scientific Literature | ||
20. | ALA5291782 | Binding | Binding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation counting | 896 | ALA5291721 | single protein format | Scientific Literature |