# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA932181 | F | Antiinflammatory activity in mouse J774A.1 cells assessed as inhibition of lipopolysaccharide-induced TNFalpha production pretreated for 2 hrs at 10 uM before LPS challenge | Mus musculus | 17 | cell-based format | Scientific Literature | ||
2. | ALA961646 | P | Hydrolytic stability assessed as compound degradation at 2 mg in sodium dihydrogen phosphate buffered 0.3% sodium carboxymethylcellulose solution at pH 7.4 after 45 hrs by HPLC | 56 | small-molecule physicochemical format | Scientific Literature | |||
3. | ALA961670 | F | Cytotoxicity against human KB cells after 72 hrs by MTT assay | Homo sapiens | 18 | cell-based format | Scientific Literature | ||
4. | ALA2405592 | B | Inhibition of 11beta-HSD2 in human kidney microsomes using [3H]-cortisol as substrate assessed as formation of cortisone at 100 uM after 30 mins by radiometric analysis relative to control | Homo sapiens | 36 | microsome format | Scientific Literature | ||
5. | ALA2405593 | B | Inhibition of 11beta-HSD2 in rat kidney microsomes using [3H]-CORT as substrate assessed as formation of 11-DHC at 100 uM after 30 mins by radiometric analysis relative to control | Rattus norvegicus | 36 | microsome format | Scientific Literature | ||
6. | ALA2405597 | B | Inhibition of human 11beta-HSD1 transfected in CHOP cells at 100 uM relative to control | Homo sapiens | 25 | cell-based format | Scientific Literature | ||
7. | ALA2405599 | B | Inhibition of 11beta-HSD1 in Sprague-Dawley rat leydig cells at 100 uM relative to control | Rattus norvegicus | 21 | assay format | Scientific Literature | ||
8. | ALA2405604 | B | Inhibition of 11beta-HSD1 in rat testis microsomes using [3H]-11-DHC as substrate assessed as formation of CORT at 100 uM after 60 to 90 mins by radiometric analysis relative to control | Rattus norvegicus | 27 | microsome format | Scientific Literature | ||
9. | ALA2405606 | B | Inhibition of 11beta-HSD1 in human liver microsomes using [3H]-cortisone as substrate assessed as formation of cortisol at 100 uM after 60 to 90 mins by radiometric analysis relative to control | Homo sapiens | 26 | microsome format | Scientific Literature | ||
10. | ALA3119976 | A | Cytotoxicity against human HL-7702 cells at 10 uM after 24 hrs by MTT assay | Homo sapiens | 34 | cell-based format | Scientific Literature | ||
11. | ALA3119977 | F | Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced IL-6 release pretreated at 10 uM for 2 hrs prior LPS challenge measured after 22 hrs post challenge by ELISA | Mus musculus | 32 | cell-based format | Scientific Literature |