Induction of heme alkylation of Fe(II) heme assessed as loss of heme at 10 uM in presence of 50% ACN-H2O with excess sodium dithionite under argon at 20 degC by spectrophotometry
Induction of heme alkylation of Fe(II) heme assessed as adduct A472 absorbance change at completion of reaction at 10 uM in presence of 50% ACN-H2O with excess sodium dithionite under argon at 20 degC by spectrophotometry
Induction of oxyl radical formation from reaction with ferrous salt in the presence of 2,2,6,6-tetramethyl-1-piperidine-1-oxyl after 24 hrs by spin-trapping and LC/MS analysis
Antimalarial activity against Plasmodium falciparum NF54 by [3H]hypoxanthine incorporation assay in presence of 3:1 ratio of compound to 4-amino-2,2,6,6,-tetramethyl-1-piperidinyloxy
Antimalarial activity against Plasmodium falciparum NF54 by [3H]hypoxanthine incorporation assay in presence of 1:1 ratio of compound to 4-amino-2,2,6,6,-tetramethyl-1-piperidinyloxy
Antimalarial activity against Plasmodium falciparum NF54 by [3H]hypoxanthine incorporation assay in presence of 1:3 ratio of compound to 4-amino-2,2,6,6,-tetramethyl-1-piperidinyloxy
Antimalarial activity against Plasmodium falciparum NF54 by [3H]hypoxanthine incorporation assay in presence of 3:1 ratio of compound to 4-carboxy-2,2,6,6,-tetramethyl-1-piperidinyloxy
Antimalarial activity against Plasmodium falciparum NF54 by [3H]hypoxanthine incorporation assay in presence of 1:1 ratio of compound to 4-carboxy-2,2,6,6,-tetramethyl-1-piperidinyloxy
Antimalarial activity against Plasmodium falciparum NF54 by [3H]hypoxanthine incorporation assay in presence of 1:3 ratio of compound to 4-carboxy-2,2,6,6,-tetramethyl-1-piperidinyloxy
Antimalarial activity against Plasmodium falciparum NF54 by [3H]hypoxanthine incorporation assay in presence of 3:1 ratio of compound to 4-hydroxy-2,2,6,6,-tetramethyl-1-piperidinyloxy