# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA932846 | F | Antagonist activity at rat recombinant P2X7 receptor assessed as inhibition of calcium flux by FLIPR assay | Rattus norvegicus | 28 | ALA1143222 | assay format | Scientific Literature | |
2. | ALA932847 | F | Antagonist activity at human recombinant P2X7 receptor assessed as inhibition of calcium flux by FLIPR assay | Homo sapiens | 28 | ALA1143222 | assay format | Scientific Literature | |
3. | ALA968795 | F | Antagonist activity at human cloned P2X7 receptor expressed in HEK293 cells assessed as inhibition of calcium flux by FLIPR assay | Homo sapiens | 59 | ALA1138502 | cell-based format | Scientific Literature | |
4. | ALA968797 | B | Activity at P2Y2 receptor up to 10 uM | 4 | ALA1138502 | single protein format | Scientific Literature | ||
5. | ALA968798 | B | Activity at P2X4 receptor up to 10 uM | 4 | ALA1138502 | single protein format | Scientific Literature | ||
6. | ALA968799 | B | Activity at P2X3 receptor up to 10 uM | 4 | ALA1138502 | single protein format | Scientific Literature | ||
7. | ALA968800 | A | Bioavailability in rat at 10 umol/kg, ip | Rattus norvegicus | 5 | ALA1138502 | organism-based format | Scientific Literature | |
8. | ALA968801 | F | Antinociceptive activity in ip dosed rat L5-L6 spinal nerve ligation model of neuropathic pain assessed as reduction in tactile allodynia | Rattus norvegicus | 5 | ALA1138502 | organism-based format | Scientific Literature | |
9. | ALA970589 | F | Antagonist activity at rat cloned P2X7 receptor expressed in HEK293 cells assessed as inhibition of calcium flux by FLIPR assay | Rattus norvegicus | 59 | ALA1138502 | cell-based format | Scientific Literature | |
10. | ALA1028693 | F | Antagonist activity at P2X7 receptor in human THP1 cells assessed as inhibition of BzATP-induced ethidium uptake | Homo sapiens | 94 | ALA1151820 | cell-based format | Scientific Literature | |
11. | ALA1028698 | B | Activity at rat P2X7 receptor expressed in HEK cells assessed as effect on BzATP-induced ethidium uptake | Rattus norvegicus | 9 | ALA1151820 | cell-based format | Scientific Literature | |
12. | ALA1030351 | A | Plasma clearance in Sprague-Dawley rat | Rattus norvegicus | 1 | ALA1151820 | organism-based format | Scientific Literature | |
13. | ALA1030352 | A | Terminal phase volume of distribution in Sprague-Dawley rat | Rattus norvegicus | 1 | ALA1151820 | organism-based format | Scientific Literature | |
14. | ALA1030353 | A | Half life in Sprague-Dawley rat | Rattus norvegicus | 1 | ALA1151820 | organism-based format | Scientific Literature | |
15. | ALA1030354 | A | Bioavailability in Sprague-Dawley rat | Rattus norvegicus | 1 | ALA1151820 | organism-based format | Scientific Literature | |
16. | ALA1048345 | F | Antagonist activity at human recombinant P2X7 receptor expressed in human 1321N1 cells assessed as inhibition of agonist-induced calcium flux by fluorometric assay | Homo sapiens | 1 | ALA1154101 | cell-based format | Scientific Literature | |
17. | ALA1048346 | F | Antagonist activity at rat recombinant P2X7 receptor expressed in human 1321N1 cells assessed as inhibition of agonist-induced calcium flux by fluorometric assay | Rattus norvegicus | 1 | ALA1154101 | cell-based format | Scientific Literature | |
18. | ALA1048347 | F | Antagonist activity at human recombinant P2X7 receptor expressed in human 1321N1 cells assessed as inhibition of BzATP-induced pore formation flux by fluorometric assay | Homo sapiens | 1 | ALA1154101 | cell-based format | Scientific Literature | |
19. | ALA1048348 | F | Antagonist activity at human recombinant P2X7 receptor expressed in human THP1 cells assessed as inhibition of BzATP-induced IL1-beta release by enzyme-linked immunosorbent assay | Homo sapiens | 1 | ALA1154101 | cell-based format | Scientific Literature | |
20. | ALA4133151 | B | Antagonist activity at human P2X7 receptor expressed in HEK293 cells assessed as inhibition of ATP-induced ethidium iodide uptake preincubated for 10 mins followed by ATP addition measured after 20 mins by spectrofluorometric analysis | Homo sapiens | 9 | ALA4130413 | cell-based format | Scientific Literature |