# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA935243 | A | Stability in CD1 mouse liver S9 fraction assessed as prodrug hydrolysis at 20 uM after 5 mins | Mus musculus | 14 | subcellular format | Scientific Literature | ||
2. | ALA935244 | A | Stability in human liver S9 fraction assessed as prodrug hydrolysis at 20 uM after 5 mins | Homo sapiens | 14 | subcellular format | Scientific Literature | ||
3. | ALA935245 | A | Cmax in mouse at 50 mg/kg, po | Mus musculus | 5 | organism-based format | Scientific Literature | ||
4. | ALA935246 | A | Cmax in mouse at 200 mg/kg, po | Mus musculus | 5 | organism-based format | Scientific Literature | ||
5. | ALA935247 | A | AUC (0 to 4 hrs) in mouse at 50 mg/kg, po | Mus musculus | 5 | organism-based format | Scientific Literature | ||
6. | ALA935248 | A | AUC (0 to 4 hrs) in mouse at 200 mg/kg, po | Mus musculus | 5 | organism-based format | Scientific Literature | ||
7. | ALA935249 | A | Ratio of AUC (0 to 4 hrs) in mouse plasma at 200 mg/kg, po to AUC (0 to 4 hrs) in mouse plasma at 50 mg/kg, po | Mus musculus | 5 | organism-based format | Scientific Literature | ||
8. | ALA935250 | A | Inhibition of human CYP1A2 | Homo sapiens | 4 | single protein format | Scientific Literature | ||
9. | ALA935251 | A | Inhibition of human CYP2C9 | Homo sapiens | 4 | single protein format | Scientific Literature | ||
10. | ALA935252 | A | Inhibition of human CYP2C19 | Homo sapiens | 4 | single protein format | Scientific Literature | ||
11. | ALA935253 | A | Inhibition of human CYP2D6 | Homo sapiens | 4 | single protein format | Scientific Literature | ||
12. | ALA935239 | A | Inhibition of human CYP3A4 using 7-benzyl-trifluoromethyl coumarin | Homo sapiens | 4 | single protein format | Scientific Literature | ||
13. | ALA935240 | A | Inhibition of human CYP3A4 using 7-benzyloxyresorufin | Homo sapiens | 4 | single protein format | Scientific Literature | ||
14. | ALA935254 | P | Stability assessed as prodrug degradation at 50 degC for 12 weeks | 1 | small-molecule physicochemical format | Scientific Literature | |||
15. | ALA935256 | P | Stability assessed as prodrug degradation at pH 4.2 and at 37 degC for 24 hrs | 1 | small-molecule physicochemical format | Scientific Literature | |||
16. | ALA935255 | P | Aqueous solubility at pH 5.8 | 1 | small-molecule physicochemical format | Scientific Literature | |||
17. | ALA935257 | F | Antitumor activity against human L2987 cells xenografted po dosed athymic mouse after 14 days | Homo sapiens | 1 | organism-based format | Scientific Literature | ||
18. | ALA935258 | F | Antitumor activity against human L2987 cells xenografted athymic mouse at 80 mg/kg/day, po after 14 days | Homo sapiens | 1 | organism-based format | Scientific Literature | ||
19. | ALA935259 | F | Antitumor activity against human L2987 cells xenografted athymic mouse at 107 mg/kg/day, po after 14 days | Homo sapiens | 1 | organism-based format | Scientific Literature |