# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA2051076 | B | Inhibition of human SGLT2 expressed in CHO-K1 cells by [14C]AMG uptake assay | Homo sapiens | 18 | cell-based format | Scientific Literature | ||
2. | ALA2051077 | B | Inhibition of human SGLT1 expressed in CHO-K1 cells by [14C]AMG uptake assay | Homo sapiens | 18 | cell-based format | Scientific Literature | ||
3. | ALA2051078 | B | Selectivity index, ratio of IC50 for human SGLT1 to IC50 for human SGLT2 | Homo sapiens | 18 | assay format | Scientific Literature | ||
4. | ALA2051079 | A | Inhibition of CYP3A4 using BFC substrate in which compound added to reaction mixture simultaneously with BFC substrate by fluorometric assay | 18 | single protein format | Scientific Literature | |||
5. | ALA2051080 | A | Inhibition of CYP3A4 using BFC substrate in which compound added to reaction mixture before addition of BFC substrate by fluorometric assay | 18 | single protein format | Scientific Literature | |||
6. | ALA2051190 | A | Potency index, ratio of IC50 for CYP3A4 (unknown origin) using BFC substrate in which compound added to reaction mixture simultaneously with BFC substrate to IC50 for CYP3A4 using BFC substrate in which compound added to reaction mixture before addition of BFC substrate | 18 | single protein format | Scientific Literature | |||
7. | ALA1811698 | B | Inhibition of human SGLT2 expressed in african green monkey COS7 cells assessed as inhibition of [14C]-methyl-alpha-D-glucopyranoside uptake after 2 hrs by scintillation counting in presence of 25 % human plasma | Homo sapiens | 16 | cell-based format | Scientific Literature | ||
8. | ALA1811699 | B | Inhibition of human SGLT1 expressed in human 293 cells assessed as inhibition of [14C]-methyl-alpha-D-glucopyranoside uptake after 1.5 hrs by scintillation counting in presence of 25 % human plasma | Homo sapiens | 27 | cell-based format | Scientific Literature | ||
9. | ALA1809841 | B | Selectivity ratio of IC50 for human SGLT1 to IC50 for human SGLT2 | Homo sapiens | 27 | assay format | Scientific Literature | ||
10. | ALA1821091 | B | Inhibition of human SGLT2 expressed in CHO cells assessed as reduction of [14C]-labeled AMG after 2 hrs by liquid scintillation counting | Homo sapiens | 15 | cell-based format | Scientific Literature | ||
11. | ALA1821092 | F | Antidiabetic activity in Sprague-Dawley rat assessed as induction of urinary glucose excretion per 200 gram of body weight at 1 mg/kg, po | Rattus norvegicus | 3 | organism-based format | Scientific Literature | ||
12. | ALA947997 | B | Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]AMG accumulation | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
13. | ALA947998 | B | Inhibition of human SGLT1 expressed in CHO cells assessed as inhibition of [14C]AMG accumulation | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
14. | ALA947999 | B | Selectivity for human SGLT2 over human SGLT1 | Homo sapiens | 5 | assay format | Scientific Literature | ||
15. | ALA948000 | B | Inhibition of rat SGLT2 expressed in CHO cells assessed as inhibition of [14C]AMG accumulation | Rattus norvegicus | 1 | cell-based format | Scientific Literature | ||
16. | ALA948001 | B | Selectivity for rat SGLT2 over rat SGLT1 | Rattus norvegicus | 1 | assay format | Scientific Literature | ||
17. | ALA948002 | B | Inhibition of human GLUT1-mediated 2-deoxyglucose uptake in human adipocytes at 20 uM | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
18. | ALA948003 | B | Inhibition of human GLUT4-mediated 2-deoxyglucose uptake in human adipocytes at 20 uM | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
19. | ALA948004 | F | Induction of glucosuria in po dosed Sprague-Dawley rat after 24 hrs | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
20. | ALA948005 | F | Induction of glucosuria in Sprague-Dawley rat assessed as glucose loss per 200 gm of body weight at 0.1 mg/kg after 24 hrs | Rattus norvegicus | 1 | organism-based format | Scientific Literature |