| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA947997 | B | Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]AMG accumulation | Homo sapiens | 5 | ALA1142359 | cell-based format | Scientific Literature | |
| 2. | ALA947998 | B | Inhibition of human SGLT1 expressed in CHO cells assessed as inhibition of [14C]AMG accumulation | Homo sapiens | 5 | ALA1142359 | cell-based format | Scientific Literature | |
| 3. | ALA947999 | B | Selectivity for human SGLT2 over human SGLT1 | Homo sapiens | 5 | ALA1142359 | assay format | Scientific Literature | |
| 4. | ALA961709 | B | Inhibition of human kidney SGLT2 assessed as renal glucose reabsorption | Homo sapiens | 8 | ALA1153320 | single protein format | Scientific Literature | |
| 5. | ALA961710 | B | Selectivity for human SGLT2 over human SGLT1 | Homo sapiens | 5 | ALA1153320 | assay format | Scientific Literature | |
| 6. | ALA1069022 | B | Inhibition of human recombinant SGLT2 expressed in CHO cells by liquid scintillation counting | Homo sapiens | 51 | ALA1157636 | cell-based format | Scientific Literature | |
| 7. | ALA1821169 | B | Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]AMG uptake after 45 mins | Homo sapiens | 17 | ALA1817561 | cell-based format | Scientific Literature | |
| 8. | ALA1821170 | B | Inhibition of human SGLT1 expressed in CHO cells assessed as [14C]AMG uptake after 45 mins | Homo sapiens | 17 | ALA1817561 | cell-based format | Scientific Literature | |
| 9. | ALA1821171 | B | Selectivity ratio of IC50 for human SGLT1 to IC50 for human SGLT2 | Homo sapiens | 17 | ALA1817561 | assay format | Scientific Literature | |
| 10. | ALA2051076 | B | Inhibition of human SGLT2 expressed in CHO-K1 cells by [14C]AMG uptake assay | Homo sapiens | 18 | ALA2046440 | cell-based format | Scientific Literature | |
| 11. | ALA2051077 | B | Inhibition of human SGLT1 expressed in CHO-K1 cells by [14C]AMG uptake assay | Homo sapiens | 18 | ALA2046440 | cell-based format | Scientific Literature | |
| 12. | ALA2051078 | B | Selectivity index, ratio of IC50 for human SGLT1 to IC50 for human SGLT2 | Homo sapiens | 18 | ALA2046440 | assay format | Scientific Literature | |
| 13. | ALA2051079 | A | Inhibition of CYP3A4 using BFC substrate in which compound added to reaction mixture simultaneously with BFC substrate by fluorometric assay | 18 | ALA2046440 | single protein format | Scientific Literature | ||
| 14. | ALA2051080 | A | Inhibition of CYP3A4 using BFC substrate in which compound added to reaction mixture before addition of BFC substrate by fluorometric assay | 18 | ALA2046440 | single protein format | Scientific Literature | ||
| 15. | ALA2051190 | A | Potency index, ratio of IC50 for CYP3A4 (unknown origin) using BFC substrate in which compound added to reaction mixture simultaneously with BFC substrate to IC50 for CYP3A4 using BFC substrate in which compound added to reaction mixture before addition of BFC substrate | 18 | ALA2046440 | single protein format | Scientific Literature | ||
| 16. | ALA3801889 | F | In vivo hypoglycemic activity in Sprague-Dawley rat assessed as urinary blood glucose level per 200g of animal body weight measured for 0 to 4 hrs at 5 mL/kg, po (Rvb = 0.26 +/- 0.04 mg) | Rattus norvegicus | 9 | ALA3797116 | organism-based format | Scientific Literature | |
| 17. | ALA3801890 | F | In vivo hypoglycemic activity in Sprague-Dawley rat assessed as urinary blood glucose level per 200g of animal body weight measured for 4 to 8 hrs at 5 mL/kg, po (Rvb = 0.14 +/- 0.03 mg) | Rattus norvegicus | 9 | ALA3797116 | organism-based format | Scientific Literature | |
| 18. | ALA3801891 | F | In vivo hypoglycemic activity in Sprague-Dawley rat assessed as urinary blood glucose level per 200g of animal body weight measured for 8 to 12 hrs at 5 mL/kg, po (Rvb = 0.21 +/- 0.01 mg) | Rattus norvegicus | 9 | ALA3797116 | organism-based format | Scientific Literature | |
| 19. | ALA3802099 | F | In vivo hypoglycemic activity in Sprague-Dawley rat assessed as urinary blood glucose level per 200g of animal body weight measured for 12 to 24 hrs at 5 mL/kg, po (Rvb = 1.45 +/- 0.28 mg) | Rattus norvegicus | 9 | ALA3797116 | organism-based format | Scientific Literature | |
| 20. | ALA3802100 | F | In vivo hypoglycemic activity in Sprague-Dawley rat assessed as urinary blood glucose level per 200g of animal body weight measured for 0 to 24 hrs at 5 mL/kg, po (Rvb = 2.03 +/- 0.34 mg) | Rattus norvegicus | 10 | ALA3797116 | organism-based format | Scientific Literature |
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