# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3635921 | Binding | Inhibition of human IDH1 R132H mutant expressed in IPTG-induced Escherichia coli BL21 cells assessed as oxidation of NADPH to NADP+ after 5 mins by spectrophotometry | Homo sapiens | 55 | ALA3632508 | cell-based format | Scientific Literature | |
2. | ALA3635922 | Binding | Inhibition of human IDH1 expressed in IPTG-induced Escherichia coli BL21 cells assessed as reduction of NADP+ to NADPH after 5 mins by spectrophotometry | Homo sapiens | 55 | ALA3632508 | cell-based format | Scientific Literature | |
3. | ALA1776446 | Functional | Antiplasmodial activity against chloroquine- and pyrimethamine-resistant Plasmodium falciparum K1 infected in human red blood cells assessed as [3H]hypoxanthine incorporation after 48 hrs by liquid scintillation counting | Plasmodium falciparum | 15 | ALA1773047 | organism-based format | Scientific Literature | |
4. | ALA1776447 | Functional | Antiparasitic activity against Trypanosoma brucei rhodesiense STIB 900 bloodstream form after 72 hrs by microplate fluorimetry | Trypanosoma brucei rhodesiense | 15 | ALA1773047 | organism-based format | Scientific Literature | |
5. | ALA1776448 | ADME | Cytotoxicity against rat L6 cells after 72 hrs by microplate fluorimetry | Rattus norvegicus | 15 | ALA1773047 | cell-based format | Scientific Literature | |
6. | ALA996208 | Functional | Inhibition of human Calu1 cell proliferation assessed as [3H]thymidine incorporation after 3 days by scintillation counting | Homo sapiens | 15 | ALA1150850 | cell-based format | Scientific Literature | |
7. | ALA1002160 | Functional | Inhibition of human HeLa cell proliferation assessed as [3H]thymidine incorporation after 3 days by scintillation counting | Homo sapiens | 15 | ALA1150850 | cell-based format | Scientific Literature | |
8. | ALA1002167 | Functional | Inhibition of human K562 cell proliferation assessed as [3H]thymidine incorporation after 3 days by scintillation counting | Homo sapiens | 15 | ALA1150850 | cell-based format | Scientific Literature | |
9. | ALA1003034 | Functional | Inhibition of human Raji cell proliferation assessed as [3H]thymidine incorporation after 3 days by scintillation counting | Homo sapiens | 15 | ALA1150850 | cell-based format | Scientific Literature | |
10. | ALA1003041 | ADME | Inhibition of african green monkey Vero cell proliferation assessed as [3H]thymidine incorporation after 3 days by scintillation counting | Chlorocebus sabaeus | 15 | ALA1150850 | cell-based format | Scientific Literature | |
11. | ALA1003048 | Functional | Inhibition of human WISH cell proliferation assessed as [3H]thymidine incorporation after 3 days by scintillation counting | Homo sapiens | 15 | ALA1150850 | cell-based format | Scientific Literature | |
12. | ALA942188 | Binding | Inhibition of NADPH oxidase in LPS-induced mouse BV2 cells assessed as NOX-dependent ROS production at 50 uM | Mus musculus | 19 | ALA1152257 | cell-based format | Scientific Literature | |
13. | ALA942189 | Binding | Inhibition of iNOS-mediated NO production in LPS-induced mouse BV2 cells | Mus musculus | 19 | ALA1152257 | cell-based format | Scientific Literature | |
14. | ALA999304 | Functional | Antioxidant activity assessed as DPPH radical scavenging activity after 30 mins | 9 | ALA1148964 | assay format | Scientific Literature | ||
15. | ALA996435 | Functional | Cytotoxicity against human A2780 cells | Homo sapiens | 10 | ALA1151217 | cell-based format | Scientific Literature | |
16. | ALA2060534 | Binding | Inhibition of SARS coronavirus nsP13 helicase activity expressed in Escherichia coli Rosetta assessed inhibition of DNA unwinding activity at 10 uM by FRET assay | SARS coronavirus | 62 | ALA2057104 | assay format | Scientific Literature | |
17. | ALA2060535 | Binding | Inhibition of HCV NS3 helicase overexpressed in Escherichia coli BL21(DE3) assessed as inhibition of DNA unwinding activity at 10 uM by FRET assay | Hepatitis C virus | 62 | ALA2057104 | assay format | Scientific Literature | |
18. | ALA2060536 | Binding | Inhibition of SARS coronavirus nsP13 ATP hydrolysis activity expressed in Escherichia coli Rosetta assessed as inhibition of inorganic phosphate release at 10 uM by AM/MG-based colometric analysis in the presence of M13 ssDNA | SARS coronavirus | 5 | ALA2057104 | assay format | Scientific Literature | |
19. | ALA2060537 | Binding | Inhibition of HCV NS3 helicase ATP hydrolysis activity overexpressed in Escherichia coli BL21(DE3) assessed as inhibition of inorganic phosphate release by AM/MG-based colometric analysis in the presence of M13 ssDNA | Hepatitis C virus | 62 | ALA2057104 | assay format | Scientific Literature |