# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA976298 | Binding | Inhibition of human wild type CFTR expressed in rat FRT cells assessed as chloride current by short-circuit current measurements | Homo sapiens | 57 | ALA1139397 | cell-based format | Scientific Literature | |
2. | ALA4495582 | Functional | SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response from peptide substrate | Severe acute respiratory syndrome coronavirus 2 | 7,212 | ALA4495564 | assay format | SARS-CoV-2 Screening Data 2020-21 | |
3. | ALA4513082 | Functional | Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging | Chlorocebus sabaeus | 7,212 | ALA4495565 | organism-based format | SARS-CoV-2 Screening Data 2020-21 | |
4. | ALA4628078 | Binding | Inhibition of NLRP3 inflammasome (unknown origin) activation in LPS-primed bone marrow derived macrophage cells at 10 uM in presence of mono sodium urate relative to control | Homo sapiens | 21 | ALA4627283 | assay format | Scientific Literature | |
5. | ALA4628079 | Binding | Inhibition of CFTR in human HT-29 cells assessed as effect on intracellular chloride efflux at 20 uM relative to control | Homo sapiens | 21 | ALA4627283 | cell-based format | Scientific Literature | |
6. | ALA4628081 | Binding | Inhibition of NLRP3 inflammasome (unknown origin) activation in LPS-primed bone marrow derived macrophage cells assessed as effect on IL-1beta production in presence of nigericin by ELISA | Homo sapiens | 21 | ALA4627283 | assay format | Scientific Literature | |
7. | ALA4628082 | ADME | Half life in human liver microsomes in presence of NADPH | Homo sapiens | 11 | ALA4627283 | microsome format | Scientific Literature | |
8. | ALA4628083 | ADME | Clearance in human liver microsomes in presence of NADPH | Homo sapiens | 11 | ALA4627283 | microsome format | Scientific Literature | |
9. | ALA4628084 | ADME | Half life in mouse liver microsomes in presence of NADPH | Mus musculus | 11 | ALA4627283 | microsome format | Scientific Literature | |
10. | ALA4628085 | ADME | Clearance in mouse liver microsomes in presence of NADPH | Mus musculus | 11 | ALA4627283 | microsome format | Scientific Literature | |
11. | ALA4628086 | Binding | Inhibition of NLRP3 inflammasome (unknown origin) activation in LPS-primed bone marrow derived macrophages assessed as inhibition of IL-1beta secretion at 5 uM in presence of nigericin by ELISA | Homo sapiens | 1 | ALA4627283 | single protein format | Scientific Literature | |
12. | ALA4628087 | Binding | Inhibition of NLRP3 inflammasome (unknown origin) activation in LPS-primed bone marrow derived macrophages assessed as inhibition of IL-1beta secretion at 5 uM in presence of ATP by ELISA | Homo sapiens | 1 | ALA4627283 | single protein format | Scientific Literature | |
13. | ALA4628088 | Binding | Inhibition of NLRP3 inflammasome (unknown origin) activation in LPS-primed bone marrow derived macrophages assessed as inhibition of IL-1beta secretion at 5 uM in presence of mono sodium urate by ELISA | Homo sapiens | 1 | ALA4627283 | single protein format | Scientific Literature | |
14. | ALA4628089 | Binding | Inhibition of NLRP3 inflammasome (unknown origin) activation in LPS-primed bone marrow derived macrophages assessed as inhibition of IL-1beta secretion in presence of nigericin by ELISA | Homo sapiens | 1 | ALA4627283 | single protein format | Scientific Literature | |
15. | ALA4628090 | Binding | Inhibition of NLRP3 inflammasome (unknown origin) activation in LPS-primed bone marrow derived macrophages assessed as inhibition of IL-1beta secretion in presence of ATP by ELISA | Homo sapiens | 1 | ALA4627283 | single protein format | Scientific Literature | |
16. | ALA4628091 | Binding | Inhibition of NLRP3 inflammasome (unknown origin) activation in LPS-primed bone marrow derived macrophages assessed as inhibition of IL-1beta secretion in presence of mono sodium urate by ELSIA | Homo sapiens | 1 | ALA4627283 | single protein format | Scientific Literature | |
17. | ALA4628092 | Binding | Inhibition of NLRP3 inflammasome (unknown origin) activation in bone marrow derived macrophage cells assessed as effect on nigericin-induced TNF-alpha secretion at 5 uM by ELISA | Homo sapiens | 1 | ALA4627283 | assay format | Scientific Literature | |
18. | ALA4628093 | Binding | Inhibition of NLRP3 inflammasome (unknown origin) activation in bone marrow derived macrophage cells assessed as effect on ATP-induced TNF-alpha secretion at 5 uM by ELISA | Homo sapiens | 1 | ALA4627283 | assay format | Scientific Literature | |
19. | ALA4628094 | Binding | Inhibition of NLRP3 inflammasome (unknown origin) activation in bone marrow derived macrophage cells assessed as effect on mono sodium urate-induced TNF-alpha secretion at 5 uM by ELISA | Homo sapiens | 1 | ALA4627283 | assay format | Scientific Literature | |
20. | ALA4628095 | Binding | Inhibition of NLRC4 inflammasome (unknown origin) activation in bone marrow derived macrophages assessed as inhibition of Salmonella-induced IL-1beta secretion at 5 uM by ELISA | Homo sapiens | 1 | ALA4627283 | single protein format | Scientific Literature |