# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA1948971 | B | Inhibition of Mycobacterium tuberculosis PTP-A using p-nitrophenyl phosphate as substrate at 25 uM measured for 10 mins by spectrofluorimetry | Mycobacterium tuberculosis | 100 | single protein format | Scientific Literature | ||
2. | ALA1948972 | B | Inhibition of Mycobacterium tuberculosis PTP-B using p-nitrophenyl phosphate as substrate at 25 uM measured for 10 mins by spectrofluorimetry | Mycobacterium tuberculosis | 100 | single protein format | Scientific Literature | ||
3. | ALA1948973 | B | Inhibition of Mycobacterium tuberculosis PTP-A using p-nitrophenyl phosphate as substrate measured for 10 mins by spectrofluorimetry | Mycobacterium tuberculosis | 33 | single protein format | Scientific Literature | ||
4. | ALA1948974 | B | Inhibition of Mycobacterium tuberculosis PTP-B using p-nitrophenyl phosphate as substrate measured for 10 mins by spectrofluorimetry | Mycobacterium tuberculosis | 33 | single protein format | Scientific Literature | ||
5. | ALA1948975 | B | Inhibition of human PTP1B expressed in Escherichia coli BL21 DE3 using p-nitrophenyl phosphate as substrate measured for 10 mins by spectrofluorimetry | Homo sapiens | 6 | assay format | Scientific Literature | ||
6. | ALA1948977 | B | Selectivity index, ratio of IC50 for human PTP1B to IC50 for Mycobacterium tuberculosis PTP-B | 3 | assay format | Scientific Literature | |||
7. | ALA1948979 | B | Competitive inhibition of Mycobacterium tuberculosis PTP-B using p-nitrophenyl phosphate as substrate measured for 10 mins by Lineweaver-Burk plot analysis | Mycobacterium tuberculosis | 3 | single protein format | Scientific Literature | ||
8. | ALA1948981 | B | Ratio of IC50 to Ki for Mycobacterium tuberculosis protein tyrosine phosphatase-B | Mycobacterium tuberculosis | 3 | assay format | Scientific Literature | ||
9. | ALA1948982 | P | Solubility of the compound | 100 | small-molecule physicochemical format | Scientific Literature | |||
10. | ALA953320 | B | Inhibition of Mycobacterium tuberculosis recombinant protein tyrosine phosphatase assessed as enzyme activity at 25 uM | Mycobacterium tuberculosis | 37 | single protein format | Scientific Literature | ||
11. | ALA2395471 | B | Competitive inhibition of Yersinia enterocolitica recombinant YopH using pNPP as substrate after 10 mins by Line-weaver Burk plot analysis | Yersinia enterocolitica | 5 | single protein format | Scientific Literature | ||
12. | ALA2395472 | B | Inhibition of Yersinia enterocolitica recombinant YopH using pNPP as substrate at 25 uM after 10 mins by spectrophotometry | Yersinia enterocolitica | 12 | single protein format | Scientific Literature | ||
13. | ALA2395473 | B | Inhibition of Yersinia enterocolitica recombinant YopH using pNPP as substrate after 10 mins by spectrophotometry | Yersinia enterocolitica | 12 | single protein format | Scientific Literature | ||
14. | ALA4340263 | F | Antitrypanosomal activity against Trypanosoma cruzi Y trypomastigotes infected in LLC-MK2-ATCC CCL7 cells assessed as reduction in parasite growth incubated for 24 hrs by Alamar blue dye based assay | Trypanosoma cruzi | 37 | organism-based format | Scientific Literature | ||
15. | ALA4340264 | A | Cytotoxicity in mouse NCTC-929 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay | Mus musculus | 37 | cell-based format | Scientific Literature | ||
16. | ALA4340265 | T | Selectivity index, ratio of CC50 for cytotoxicity in mouse NCTC-929 cells to EC50 for Antitrypanosomal activity against Trypanosoma cruzi trypomastigotes infected in LLC-MK2-ATCC CCL7 cells | 37 | cell-based format | Scientific Literature |