# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA998472 | B | Displacement of [3H]D-Asp from human EAAT1 receptor expressed in HEK293 cells | Homo sapiens | 28 | ALA1140931 | cell-based format | Scientific Literature | |
2. | ALA998473 | B | Displacement of [3H]D-Asp from human EAAT2 receptor expressed in HEK293 cells | Homo sapiens | 26 | ALA1140931 | cell-based format | Scientific Literature | |
3. | ALA998474 | B | Displacement of [3H]D-Asp from human EAAT3 receptor expressed in HEK293 cells | Homo sapiens | 27 | ALA1140931 | cell-based format | Scientific Literature | |
4. | ALA998475 | B | Activity of human EAAT1 expressed in HEK293 cells up to 100 uM | Homo sapiens | 1 | ALA1140931 | cell-based format | Scientific Literature | |
5. | ALA998476 | B | Activity of human EAAT2 expressed in HEK293 cells up to 100 uM | Homo sapiens | 1 | ALA1140931 | cell-based format | Scientific Literature | |
6. | ALA998477 | B | Activity of human EAAT3 expressed in HEK293 cells up to 100 uM | Homo sapiens | 1 | ALA1140931 | cell-based format | Scientific Literature | |
7. | ALA998478 | B | Activity at human EAAT1 expressed in HEK293 cells assessed as inhibition of Glu-induced fluorescent response by FLIPR membrane potential blue assay | Homo sapiens | 2 | ALA1140931 | cell-based format | Scientific Literature | |
8. | ALA998481 | B | Activity at rat EAAT1 expressed in TSA201 cells assessed as inhibition of Glu-induced fluorescent response by FLIPR membrane potential blue assay | Rattus norvegicus | 1 | ALA1140931 | cell-based format | Scientific Literature | |
9. | ALA998482 | B | Selectivity of IC50 for human EAAT2 to IC50 for human EAAT1 expressed in HEK293 cells | Homo sapiens | 1 | ALA1140931 | cell-based format | Scientific Literature | |
10. | ALA998483 | B | Selectivity of IC50 for human EAAT3 to IC50 for human EAAT1 expressed in HEK293 cells | Homo sapiens | 1 | ALA1140931 | cell-based format | Scientific Literature | |
11. | ALA1261598 | B | Inhibition of human EAAT1 expressed in HEK293 cells by [3H]D-Asp uptake assay | Homo sapiens | 21 | ALA1255223 | cell-based format | Scientific Literature | |
12. | ALA1261601 | B | Inhibition of human EAAT2 expressed in HEK293 cells at 300 uM by [3H]D-Asp uptake assay | Homo sapiens | 11 | ALA1255223 | cell-based format | Scientific Literature | |
13. | ALA1261605 | B | Inhibition of human EAAT3 expressed in HEK293 cells at 300 uM by [3H]D-Asp uptake assay | Homo sapiens | 11 | ALA1255223 | cell-based format | Scientific Literature | |
14. | ALA1261607 | A | Terminal half life in Sprague-Dawley rat at 10 mg/kg | Rattus norvegicus | 1 | ALA1255223 | organism-based format | Scientific Literature | |
15. | ALA1261608 | A | Drug level in Sprague-Dawley rat brain at 10 mg/kg | Rattus norvegicus | 1 | ALA1255223 | organism-based format | Scientific Literature | |
16. | ALA2067159 | B | Inhibition of human EAAT1 expressed in HEK293 cells assessed as inhibition of 3[H]-D-Aspartate uptake after 6 mins by scintillation counting method | Homo sapiens | 16 | ALA2062411 | cell-based format | Scientific Literature | |
17. | ALA4357106 | B | Inhibition of EAAT1 (unknown origin) stably expressed in HEK293 cells assessed as reduction in [14C]glutamate uptake incubated for 5 mins by microbeta scintillation counting method | Homo sapiens | 1 | ALA4354829 | cell-based format | Scientific Literature | |
18. | ALA4495582 | F | SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response from peptide substrate | Severe acute respiratory syndrome coronavirus 2 | 7,212 | ALA4495564 | assay format | SARS-CoV-2 Screening Data 2020-21 | |
19. | ALA4513082 | F | Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging | Chlorocebus sabaeus | 7,212 | ALA4495565 | organism-based format | SARS-CoV-2 Screening Data 2020-21 | |
20. | ALA5209616 | F | Inhibition of the Excitatory Amino Acid Transporter 1 (EAAT1, SLC1A3) as assessed by a phenotypic impedance-based assay detecting changes in cell morphology by L-glutamate uptake in HEK-293 JumpIN-SLC1A3 cells (PubChem AID: 1745862) | Homo sapiens | 6 | ALA5209591 | cell-based format | RESOLUTE - Research Empowerment on Solute Carriers |