| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA995941 | B | Inhibition of 6-His tagged recombinant c-Myc353-437 gene binding to Max(S) protein assessed as disruption of heterodimer formation by circular dichroism assay | 12 | assay format | Scientific Literature | |||
| 2. | ALA995943 | F | Cytotoxicity against human HL60 cells by MTS assay | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 3. | ALA1025532 | B | Decrease in c-Myc-p21MAX heterodimer binding to E-box DNA at 50 uM by EMSA method | 1 | assay format | Scientific Literature | |||
| 4. | ALA1025533 | B | Binding affinity to fluorescently tagged c-Myc-p21MAX heterodimer assessed as competitive constant by using fluorescence polarization titration | 1 | assay format | Scientific Literature | |||
| 5. | ALA3223391 | F | Antiproliferative activity against human HL60 cells | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 6. | ALA3223396 | B | Binding affinity to c-MYC (353 to 437) (unknown origin) by fluorescence polarization assay | Homo sapiens | 2 | single protein format | Scientific Literature | ||
| 7. | ALA3428868 | F | Cell cycle arrest in human HL60 cells assessed as accumulation at G0/G1 phase at 20 uM after 24 hrs by propidium iodide staining-based flow cytometric analysis (Rvb = 39%) | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 8. | ALA3428869 | F | Cell cycle arrest in human HL60 cells assessed as accumulation at S phase at 20 uM after 24 hrs by propidium iodide staining-based flow cytometric analysis (Rvb = 49%) | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 9. | ALA3428870 | F | Cell cycle arrest in human HL60 cells assessed as accumulation at G2/M phase at 20 uM after 24 hrs by propidium iodide staining-based flow cytometric analysis (Rvb = 11.2%) | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 10. | ALA3428871 | F | Cell cycle arrest in human HL60 cells assessed as accumulation at G0/G1 phase at 40 uM after 24 hrs by propidium iodide staining-based flow cytometric analysis (Rvb = 39%) | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 11. | ALA3428872 | F | Cell cycle arrest in human HL60 cells assessed as accumulation at S phase at 40 uM after 24 hrs by propidium iodide staining-based flow cytometric analysis (Rvb = 49%) | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 12. | ALA3428873 | F | Cell cycle arrest in human HL60 cells assessed as accumulation at G2/M phase at 40 uM after 24 hrs by propidium iodide staining-based flow cytometric analysis (Rvb = 11.2%) | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 13. | ALA3428880 | B | Induction of dissociation of c-May-Max in human HL60 cells at 40 to 72 uM after 6 hrs by Co-immunoprecipitation (Co-IP) assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 14. | ALA3991966 | B | Inhibition of c-Myc/Max interaction in human HL60 cells assessed as cell growth inhibition after 5 days by trypan blue exclusion assay | Homo sapiens | 12 | cell-based format | Patent Bioactivity Data | ||
| 15. | ALA3991967 | B | Inhibition of c-Myc/Max interaction in human HL60 nuclear extracts at 100 to 200 uM after 30 mins by co-immunoprecipitation assay | Homo sapiens | 12 | protein format | Patent Bioactivity Data | ||
| 16. | ALA3991968 | A | Effect on absolute levels of c-Myc in human HL60 nuclear extracts at 100 to 200 uM after 30 mins by co-immunoprecipitation assay | Homo sapiens | 12 | cell-based format | Patent Bioactivity Data | ||
| 17. | ALA3991969 | A | Effect on absolute levels of Max in human HL60 nuclear extracts at 100 to 200 uM after 30 mins by co-immunoprecipitation assay | Homo sapiens | 12 | cell-based format | Patent Bioactivity Data | ||
| 18. | ALA3991970 | B | Inhibition of recombinant human His6 tagged c-Myc bHLH-LZ domain (353 to 439 residues) with GGCD extension at C-terminus/recombinant human full length His6 tagged Max (151 residues) expressed in Escherichia coli assessed as reduction of heterodimer binding to HEX labeled E-box-containing DNA after 90 mins by electrophoretic mobility shift assay | Homo sapiens | 12 | assay format | Patent Bioactivity Data | ||
| 19. | ALA3991971 | B | Inhibition of human His6 tagged Max (160 residues) homodimer binding to HEX labeled E-box-containing DNA after 90 mins by electrophoretic mobility shift assay | Homo sapiens | 12 | single protein format | Patent Bioactivity Data | ||
| 20. | ALA3991972 | B | Binding affinity to recombinant human His6 tagged c-Myc bHLH-LZ domain (353 to 439 residues) with GGCD extension at C-terminus expressed in Escherichia coli BL21 DE3 (pLysS) at 25 uM by fluorescence polarization assay | Homo sapiens | 13 | assay format | Patent Bioactivity Data |
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