# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA1169092 | Binding | Induction of ribosome to readthrough in-frame UGA codon of renilla/firefly PCDH15 R3X nonsense mutant gene transfected in rabbit reticulocyte assessed as reduction in overall translation at 5 to 20 uM after 16 hrs dual-luciferase reporter gene assay | Oryctolagus cuniculus | 4 | ALA1165913 | subcellular format | Scientific Literature | |
2. | ALA1166118 | Binding | Induction of ribosome to readthrough in-frame UGA codon of renilla/firefly PCDH15 R245X nonsense mutant gene transfected in rabbit reticulocyte assessed as reduction in overall translation at 5 to 20 uM after 16 hrs dual-luciferase reporter gene assay | Oryctolagus cuniculus | 4 | ALA1165913 | subcellular format | Scientific Literature | |
3. | ALA1166119 | Binding | Induction of ribosome to readthrough in-frame UGA codon of renilla/firefly CFTR G542X nonsense mutant gene transfected in rabbit reticulocyte assessed as reduction in overall translation at 5 to 20 uM after 16 hrs dual-luciferase reporter gene assay | Oryctolagus cuniculus | 4 | ALA1165913 | subcellular format | Scientific Literature | |
4. | ALA1166120 | Binding | Induction of ribosome to readthrough in-frame UGA codon of renilla/firefly CFTR W1282X nonsense mutant gene transfected in rabbit reticulocyte assessed as reduction in overall translation at 5 to 20 uM after 16 hrs dual-luciferase reporter gene assay | Oryctolagus cuniculus | 4 | ALA1165913 | subcellular format | Scientific Literature | |
5. | ALA1166121 | Binding | Induction of ribosome to readthrough in-frame UGA codon associated with renilla/firefly dystrophin R3381X nonsense mutant gene transfected in rabbit reticulocyte assessed as reduction in overall translation at 5 to 20 uM after 16 hrs dual-luciferase reporter gene assay | Oryctolagus cuniculus | 4 | ALA1165913 | subcellular format | Scientific Literature | |
6. | ALA1166122 | Binding | Induction of ribosome to readthrough in-frame UAG codon of renilla/firefly IDUA Q70X nonsense mutant gene transfected in rabbit reticulocyte assessed as reduction in overall translation at 5 to 20 uM after 16 hrs dual-luciferase reporter gene assay | Oryctolagus cuniculus | 4 | ALA1165913 | subcellular format | Scientific Literature | |
7. | ALA1166127 | ADME | Cytotoxicity against HEK293 cells after 48 hrs by XTT assay | Homo sapiens | 6 | ALA1165913 | cell-based format | Scientific Literature | |
8. | ALA1166951 | Binding | Inhibition of ribosomal activity in Escherichia coli strain B assessed as inhibition of translation after 60 mins by coupled transcription/translation assay | Escherichia coli B | 6 | ALA1165913 | subcellular format | Scientific Literature | |
9. | ALA1166952 | Binding | Inhibition of ribosomal activity in Spodoptera frugiperda Sf21 cells assessed as inhibition of translation after 60 mins by fluorescence assay | Spodoptera frugiperda | 6 | ALA1165913 | subcellular format | Scientific Literature | |
10. | ALA1166953 | Functional | Antibacterial activity against Escherichia coli R477-100 by double-microdilution method | Escherichia coli | 6 | ALA1165913 | organism-based format | Scientific Literature | |
11. | ALA1166954 | Functional | Antibacterial activity against Bacillus subtilis ATCC 6633 by double-microdilution method | Bacillus subtilis | 6 | ALA1165913 | organism-based format | Scientific Literature | |
12. | ALA1166955 | Binding | Ratio of gentamicin to compound antitranslational activity against prokaryotic ribosome-mediated translation | 2 | ALA1165913 | subcellular format | Scientific Literature | ||
13. | ALA1166956 | Binding | Ratio of paromomycin to compound antitranslational activity against prokaryotic ribosome-mediated translation | 2 | ALA1165913 | subcellular format | Scientific Literature | ||
14. | ALA1019316 | Binding | Binding affinity to human cytoplasmic ribosomal RNA A-site | Homo sapiens | 2 | ALA1138589 | nucleic acid format | Scientific Literature | |
15. | ALA1019317 | Binding | Suppression of CFTR G542X nonsense mutant cDNA translation in TNT rabbit reticulocyte lysate transcription translation system at 25 to 100 uM at 30 degC after 90 mins by luciferase reporter gene assay | 4 | ALA1138589 | assay format | Scientific Literature | ||
16. | ALA1019318 | Binding | Suppression of CFTR W1282X nonsense mutant cDNA translation in TNT rabbit reticulocyte lysate transcription translation system at 25 to 100 uM at 30 degC after 90 mins by luciferase reporter gene assay | 4 | ALA1138589 | assay format | Scientific Literature | ||
17. | ALA1019319 | Binding | Suppression of Dystrophin R3381X nonsense mutant cDNA translation in TNT rabbit reticulocyte lysate transcription translation system at 25 to 100 uM at 30 degC after 90 mins by luciferase reporter gene assay | 4 | ALA1138589 | assay format | Scientific Literature | ||
18. | ALA1019320 | Binding | Suppression of IDUA Q70X nonsense mutant cDNA translation in TNT rabbit reticulocyte lysate transcription translation system at 25 to 100 uM at 30 degC after 90 mins by luciferase reporter gene assay | 4 | ALA1138589 | assay format | Scientific Literature | ||
19. | ALA1019321 | Binding | Suppression of PCDH15 R3X nonsense mutant cDNA translation in TNT rabbit reticulocyte lysate transcription translation system at 25 to 100 uM at 30 degC after 90 mins by luciferase reporter gene assay | 4 | ALA1138589 | assay format | Scientific Literature | ||
20. | ALA1019322 | Toxicity | Toxicity against HEK293 cells | Homo sapiens | 4 | ALA1138589 | cell-based format | Scientific Literature |