# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA1020203 | Binding | Inhibition of DNA topoisomerase 1 in mouse P388/S cells assessed as formation of topoisomerase 1-DNA complex by proteinase K/SDS method | Mus musculus | 30 | ALA1138509 | cell-based format | Scientific Literature | |
2. | ALA1020204 | Binding | Inhibition of human DNA topoisomerase 1-mediated DNA cleavage assessed as relaxation of supercoiled pBR322 plasmid DNA after 15 mins by densitometer | Homo sapiens | 30 | ALA1138509 | single protein format | Scientific Literature | |
3. | ALA1020205 | Functional | Cytotoxicity against mouse P388/S cells after 72 hrs by colorimetric tetrazolium-formazan method | Mus musculus | 30 | ALA1138509 | cell-based format | Scientific Literature | |
4. | ALA1020206 | Functional | Cytotoxicity against human MKN45 cells after 72 hrs | Homo sapiens | 30 | ALA1138509 | cell-based format | Scientific Literature | |
5. | ALA1020207 | Functional | Cytotoxicity against human DLD1 cells after 72 hrs | Homo sapiens | 30 | ALA1138509 | cell-based format | Scientific Literature | |
6. | ALA1020208 | Functional | Cytotoxicity against human HeLa cells after 72 hrs | Homo sapiens | 29 | ALA1138509 | cell-based format | Scientific Literature | |
7. | ALA1020209 | Binding | Inhibition of PKC | 4 | ALA1138509 | assay format | Scientific Literature | ||
8. | ALA1020210 | Binding | Inhibition of EGFR | 4 | ALA1138509 | single protein format | Scientific Literature | ||
9. | ALA1020212 | Functional | Antitumor activity in human MKN45 cells xenografted iv dosed nude mouse assessed as tumor growth inhibition administered 5 times per week for 2 weeks at tumor growth of >= 0.2 cm2 | Homo sapiens | 2 | ALA1138509 | organism-based format | Scientific Literature | |
10. | ALA1020213 | Toxicity | Toxicity in human MKN45 cells xenografted iv dosed nude mouse | Mus musculus | 4 | ALA1138509 | organism-based format | Scientific Literature | |
11. | ALA1021037 | Toxicity | Safety margin, ratio of LD10 for nude mouse to GID75 for human MKN45 cells | 4 | ALA1138509 | cell-based format | Scientific Literature | ||
12. | ALA1021038 | Functional | Antitumor activity in human MX1 cells xenografted iv dosed nude mouse assessed as tumor growth inhibition administered twice per week for 2 weeks | Homo sapiens | 3 | ALA1138509 | organism-based format | Scientific Literature | |
13. | ALA1021040 | Toxicity | Toxicity in human MX1 cells xenografted iv dosed nude mouse | Mus musculus | 4 | ALA1138509 | organism-based format | Scientific Literature | |
14. | ALA1021041 | Toxicity | Safety margin, ratio of LD10 for nude mouse to GID75 for human MX1 cells | 4 | ALA1138509 | cell-based format | Scientific Literature |