# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA1021965 | B | Displacement of [125I]PYY from human recombinant neuropeptide Y5 receptor expressed in mouse LMtk- cells | Homo sapiens | 28 | ALA1138528 | cell-based format | Scientific Literature | |
2. | ALA1008329 | B | Displacement of [125I]PYY from human recombinant NPY Y5 receptor expressed in mouse LMtk- cells | Homo sapiens | 35 | ALA1136978 | cell-based format | Scientific Literature | |
3. | ALA1008332 | A | Oral bioavailability in rat at 3 mg/kg, iv and 10 mg/kg, po | Rattus norvegicus | 8 | ALA1136978 | organism-based format | Scientific Literature | |
4. | ALA1008333 | A | Plasma concentration in rat at 10 mg/kg, po after 2 hrs | Rattus norvegicus | 10 | ALA1136978 | organism-based format | Scientific Literature | |
5. | ALA1008334 | A | Drug level in rat brain at 10 mg/kg, po after 2 hrs measured per gram of tissue | Rattus norvegicus | 10 | ALA1136978 | organism-based format | Scientific Literature | |
6. | ALA1008335 | A | Drug level in rat cerebrospinal fluid at 10 mg/kg, po after 2 hrs | Rattus norvegicus | 9 | ALA1136978 | organism-based format | Scientific Literature | |
7. | ALA1008336 | B | Displacement of [125I]PYY from rat NPY Y5 receptor | Rattus norvegicus | 3 | ALA1136978 | single protein format | Scientific Literature | |
8. | ALA1008337 | B | Displacement of [125I]PYY from mouse NPY Y5 receptor | Mus musculus | 1 | ALA1136978 | single protein format | Scientific Literature | |
9. | ALA1008338 | B | Inhibition of human NPY Y1 receptor | Homo sapiens | 1 | ALA1136978 | single protein format | Scientific Literature | |
10. | ALA1008339 | B | Inhibition of human NPY Y2 receptor | Homo sapiens | 1 | ALA1136978 | single protein format | Scientific Literature | |
11. | ALA1008340 | B | Inhibition of human NPY Y4 receptor | Homo sapiens | 1 | ALA1136978 | single protein format | Scientific Literature | |
12. | ALA1008341 | F | Antagonist activity at human recombinant NPY Y5 receptor expressed in mouse LMtk- cells assessed as inhibition of NPY-induced Ca2+ increase | Homo sapiens | 1 | ALA1136978 | cell-based format | Scientific Literature | |
13. | ALA1008342 | F | Inhibition of D-Trp34NPY-induced food intake in orally dosed Sprague-Dawley rat measured after 2 hrs of inducer challenge | Rattus norvegicus | 3 | ALA1136978 | organism-based format | Scientific Literature | |
14. | ALA1008343 | F | Inhibition of NPY-induced food intake in Sprague-Dawley rat up to 10 mg/kg, po | Rattus norvegicus | 1 | ALA1136978 | organism-based format | Scientific Literature | |
15. | ALA1008344 | P | Solubility in artificial gastric fluid at pH 1.2 | 28 | ALA1136978 | small-molecule physicochemical format | Scientific Literature | ||
16. | ALA1008345 | P | Solubility in artificial intestinal fluid at pH 6.8 | 28 | ALA1136978 | small-molecule physicochemical format | Scientific Literature | ||
17. | ALA1008347 | F | Ex vivo receptor occupancy in high fat fed C57BL/6J mouse Lepr db/db model at 10 mg/kg, po for 16 hrs | Mus musculus | 1 | ALA1136978 | organism-based format | Scientific Literature |