# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA974422 | Binding | Induction of mouse cysteine-less MDR3 ATPase activity relative to basal activity | Mus musculus | 26 | ALA1138514 | single protein format | Scientific Literature | |
2. | ALA974425 | Binding | Induction of mouse cysteine-less MDR3 ATPase activity by apparent Michaelis-Menten constant | Mus musculus | 26 | ALA1138514 | single protein format | Scientific Literature | |
3. | ALA2214941 | ADME | Ratio of permeability from apical to basal side of MDCK2 cells expressing MDR1 assessed as fraction of mass extracted by methanol wash at 5 uM in presence of LSN 335984 to permeability from apical to basal side of MDCK2 cells expressing MDR1 assessed as fraction of mass extracted by methanol wash at 5 uM in absence of LSN 335984 | Canis lupus familiaris | 12 | ALA2203082 | cell-based format | Scientific Literature | |
4. | ALA2214942 | ADME | Permeability from apical to basal side of MDCK2 cells expressing MDR1 assessed as fraction of mass extracted by methanol wash at 5 uM after 1 hr by LC-MS/MS analysis in presence of LSN 335984 | Canis lupus familiaris | 12 | ALA2203082 | cell-based format | Scientific Literature | |
5. | ALA2214943 | ADME | Permeability from apical to basal side of MDCK2 cells expressing MDR1 assessed as fraction of mass extracted by methanol wash at 5 uM after 1 hr by LC-MS/MS analysis | Canis lupus familiaris | 12 | ALA2203082 | cell-based format | Scientific Literature | |
6. | ALA2214944 | ADME | Passive permeability across MDCK2 cells expressing MDR1 at 5 uM after 1 hr by LC-MS/MS analysis in presence of LSN 335984 | Canis lupus familiaris | 12 | ALA2203082 | cell-based format | Scientific Literature | |
7. | ALA2214945 | ADME | Ratio of permeability from basal to apical side of MDCK2 cells expressing MDR1 in absence of LSN 335984 to permeability from basal to apical side of MDCK2 cells expressing MDR1 in presence of LSN 335984 | Canis lupus familiaris | 12 | ALA2203082 | cell-based format | Scientific Literature | |
8. | ALA2214946 | ADME | Permeability from basal to apical side of MDCK2 cells expressing MDR1 at 5 uM after 1 hr by LC-MS/MS analysis in presence of LSN 335984 | Canis lupus familiaris | 12 | ALA2203082 | cell-based format | Scientific Literature | |
9. | ALA2214947 | ADME | Permeability from basal to apical side of MDCK2 cells expressing MDR1 at 5 uM after 1 hr by LC-MS/MS analysis | Canis lupus familiaris | 12 | ALA2203082 | cell-based format | Scientific Literature | |
10. | ALA2214948 | ADME | Permeability from apical to basal side of MDCK2 cells expressing MDR1 at 5 uM after 1 hr by LC-MS/MS analysis in presence of LSN 335984 | Canis lupus familiaris | 12 | ALA2203082 | cell-based format | Scientific Literature | |
11. | ALA2214949 | ADME | Permeability from apical to basal side of MDCK2 cells expressing MDR1 at 5 uM after 1 hr by LC-MS/MS analysis | Canis lupus familiaris | 12 | ALA2203082 | cell-based format | Scientific Literature | |
12. | ALA2214950 | Physicochemical | n-Octanol-water partition coefficient, log P of the compound at pH 7.4 by shake flask method | 10 | ALA2203082 | small-molecule physicochemical format | Scientific Literature | ||
13. | ALA2214952 | Binding | Inhibition of MDR1 transfected in MDCK2 cells assessed as increase in calcein AM uptake at 2.5*10'-5 M incubated for 30 mins prior to calcein AM influx measured after 20 mins by fluorimetric analysis relative to LSN 335984 | 12 | ALA2203082 | cell-based format | Scientific Literature | ||
14. | ALA2214953 | Binding | Inhibition of MDR1 transfected in MDCK2 cells assessed as increase in calcein AM uptake at 5*10'-6 M incubated for 30 mins prior to calcein AM influx measured after 20 mins by fluorimetric analysis relative to LSN 335984 | 12 | ALA2203082 | cell-based format | Scientific Literature | ||
15. | ALA2214954 | Binding | Inhibition of MDR1 transfected in MDCK2 cells assessed as increase in calcein AM uptake incubated for 30 mins prior to calcein AM influx measured after 20 mins by fluorimetric analysis | 12 | ALA2203082 | cell-based format | Scientific Literature | ||
16. | ALA2214956 | Binding | Binding affinity to human His10-tagged P-gp expressed in BHK cells assessed as induction of ATPase activity measured as inorganic phosphate release by spectrophotometric analysis | Homo sapiens | 13 | ALA2203082 | cell-based format | Scientific Literature | |
17. | ALA2214957 | Binding | Binding affinity to human His10-tagged P-gp expressed in BHK cells assessed as induction of ATPase activity measured as inorganic phosphate release by spectrophotometric analysis relative to control | Homo sapiens | 13 | ALA2203082 | cell-based format | Scientific Literature |