| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA977683 | B | Inhibition of rat liver microsomal ACAT | Rattus norvegicus | 7 | assay format | Scientific Literature | ||
| 2. | ALA4341607 | F | Induction of apoptosis in human MDA-MB-231 cells assessed as increase in cleaved caspase 3 expression at 20 to 80 ug/ml by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 3. | ALA4341608 | F | Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability after 24 hrs by MTT assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 4. | ALA4341609 | F | Induction of apoptosis in human MDA-MB-231 cells assessed as early apoptotic cells at 80 ug/ml after 24 hrs by Annexin-V-FITC/propidium iodide staining based FACS analysis relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 5. | ALA4341610 | F | Induction of apoptosis in human MDA-MB-231 cells assessed as increase in late apoptotic cells at 20 to 40 ug/ml after 24 hrs by Annexin-V-FITC/propidium iodide staining based FACS analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 6. | ALA4341611 | F | Induction of apoptosis in human MDA-MB-231 cells assessed as down regulation of PARP1 expression by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 7. | ALA4341612 | B | Inhibition of EGFR phosphorylation in human MDA-MB-231 cells by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 8. | ALA4341613 | B | Inhibition of EGFR L858R mutant (unknown origin) using polyE4Y1 as substrate measured after 60 mins | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 9. | ALA4341614 | F | Induction of apoptosis in human MDA-MB-231 cells assessed as increase in apoptotic cells after 24 hrs in presence of lapatinib by Annexin-V-FITC/propidium iodide staining based FACS analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 10. | ALA4341615 | F | Induction of apoptosis in human MDA-MB-231 cells assessed as increase in apoptotic cells after 24 hrs in presence of EGFR siRNA by Annexin-V-FITC/propidium iodide staining based FACS analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 11. | ALA4341616 | F | Antitumor activity against human MDA-MB-231 cells xenografted in athymic BALB/c nude mouse assessed as decrease in tumor volume at 1.25 to 5 mg/kg, po administered every two days for 28 days measured post-last dose by caliper method | Homo sapiens | 1 | organism-based format | Scientific Literature | ||
| 12. | ALA4341617 | F | Down regulation of RAS expression in athymic BALB/c nude mouse xenografted with human MDA-MB-231 cells at 1.25 to 5 mg/kg, sc administered every two days for 28 days by Western blot analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 13. | ALA4341618 | F | Down regulation of PI3K expression athymic BALB/c nude mouse xenografted with human MDA-MB-231 cells at 1.25 to 5 mg/kg, sc administered every two days for 28 days by Western blot analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 14. | ALA4341619 | F | Down regulation of mTOR expression in athymic BALB/c nude mouse xenografted with human MDA-MB-231 cells at 1.25 to 5 mg/kg, sc administered every two days for 28 days by Western blot analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 15. | ALA4341620 | F | Effect on RAF expression in athymic BALB/c nude mouse xenografted with human MDA-MB-231 cells at 1.25 to 5 mg/kg, sc administered every two days for 28 days by Western blot analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 16. | ALA4341621 | F | Induction of ERK phosphorylation in athymic BALB/c nude mouse xenografted with human MDA-MB-231 cells at 1.25 to 5 mg/kg, sc administered every two days for 28 days by Western blot analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 17. | ALA4341622 | F | Down regulation of AKT phosphorylation in athymic BALB/c nude mouse xenografted with human MDA-MB-231 cells at 1.25 to 5 mg/kg, sc administered every two days for 28 days by Western blot analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 18. | ALA4341623 | F | Effect on MEK expression in athymic BALB/c nude mouse xenografted with human MDA-MB-231 cells at 1.25 to 5 mg/kg, sc administered every two days for 28 days by western blot analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 19. | ALA4341624 | F | Effect on MEK phosphorylation in athymic BALB/c nude mouse xenografted with human MDA-MB-231 cells at 1.25 to 5 mg/kg, sc administered every two days for 28 days by western blot analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 20. | ALA4341625 | F | Increase in ERK expression in in athymic BALB/c nude mouse xenografted with human MDA-MB-231 cells at 1.25 to 5 mg/kg, sc administered every two days for 28 days by Western blot analysis | Mus musculus | 1 | organism-based format | Scientific Literature |
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