# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3792267 | Functional | Inhibition of LPS-induced paracellular gap formation in HUVEC cells assessed as formation of dense F-actin rings at 10 uM after 6 hrs by immunofluorescence staining assay | Homo sapiens | 3 | ALA3784988 | cell-based format | Scientific Literature | |
2. | ALA3792268 | Functional | Inhibition of LPS induced barrier disruption in HUVEC cells assessed as evans blue-bound albumin complex flux after 6 hrs by spectrophotometric method | Homo sapiens | 3 | ALA3784988 | cell-based format | Scientific Literature | |
3. | ALA3792269 | Functional | Vascular barrier protective effect in mouse assessed as inhibition of LPS induced peritoneal leakage of evans blue dye at 2 to 10 uM after 30 mins | Mus musculus | 3 | ALA3784988 | organism-based format | Scientific Literature | |
4. | ALA3788036 | ADME | Cytotoxicity against HUVEC cells assessed as cell viability upto 30 uM by MTT assay | Homo sapiens | 3 | ALA3784988 | cell-based format | Scientific Literature | |
5. | ALA3788037 | Functional | Reduction in LPS-induced human Vybrant DiD labelled neutrophil adhesion in HUVEC cells after 6 hrs by fluorescence analysis | Homo sapiens | 3 | ALA3784988 | cell-based format | Scientific Literature | |
6. | ALA3788038 | Toxicity | Toxicity in HUVEC cells assessed as effect on human Vybrant DiD labelled neutrophil adhesion at 10 uM after 6 hrs by fluorescence analysis | Homo sapiens | 3 | ALA3784988 | cell-based format | Scientific Literature | |
7. | ALA3788039 | Functional | Reduction in LPS-induced human neutrophil migration index in HUVEC cells after 6 hrs by crystal violet staining-based microscopic analysis | Homo sapiens | 3 | ALA3784988 | cell-based format | Scientific Literature | |
8. | ALA3788040 | Toxicity | Toxicity in HUVEC cells assessed as effect on human neutrophil migration index at 10 uM after 6 hrs by crystal violet staining-based microscopic analysis | Homo sapiens | 3 | ALA3784988 | cell-based format | Scientific Literature | |
9. | ALA3788041 | Functional | Reduction in LPS-induced leukocyte migration in mouse peritoneal cavity at 2 to 10 uM after 6 hrs by crystal violet staining-based light microscopic analysis | Mus musculus | 3 | ALA3784988 | organism-based format | Scientific Literature | |
10. | ALA3788044 | Functional | Reduction in CLP-induced sepsis lethality in C57BL/6 mouse at 4.20 ug, iv administered at 12 hrs post CLP challenge measured every 6 hrs for 132 hrs | Mus musculus | 1 | ALA3784988 | organism-based format | Scientific Literature | |
11. | ALA3788047 | Functional | Reduction in CLP-induced sepsis lethality in C57BL/6 mouse assessed as increase in survival rate at 4.20 ug, iv administered first dose at 12 hrs post CLP challenge followed by second dose at 50 hrs post CLP challenge measured every 6 hrs after CLP challenge for 132 hrs | Mus musculus | 1 | ALA3784988 | organism-based format | Scientific Literature | |
12. | ALA3788048 | Functional | Induction of permeabilization in HUVEC assessed as evans blue-bound albumin complex flux at 10 uM after 6 hrs by spectrophotometric method | Homo sapiens | 3 | ALA3784988 | cell-based format | Scientific Literature | |
13. | ALA993872 | Functional | Antimicrobial activity against Vibrio anguillarum after 24 to 48 hrs | Vibrio anguillarum | 15 | ALA1147226 | organism-based format | Scientific Literature | |
14. | ALA4036567 | Functional | Cytotoxicity against human NCI-H460 cells incubated for 24 hrs by MTT assay | Homo sapiens | 16 | ALA4033740 | cell-based format | Scientific Literature | |
15. | ALA5121453 | Functional | Antibacterial activity aginst Bacillus subtilis DSM 10 assessed as inhibition of bacterial growth incubated for overnight by serial dilution method | Bacillus subtilis | 13 | ALA5120760 | organism-based format | Scientific Literature | |
16. | ALA5121454 | Functional | Antifungal activity against Candida albicans DSM 1665 assessed as inhibition of fungal growth incubated for overnight by serial dilution method | Candida albicans | 8 | ALA5120760 | organism-based format | Scientific Literature | |
17. | ALA5121455 | Functional | Antibacterial activity against Chromobacterium violaceum DSM 30191 assessed as inhibition of bacterial growth incubated for overnight by serial dilution method | Chromobacterium violaceum | 9 | ALA5120760 | organism-based format | Scientific Literature | |
18. | ALA5121456 | Functional | Antibacterial activity against Escherichia coli DSM 1116 assessed as inhibition of bacterial growth incubated for overnight by serial dilution method | Escherichia coli | 8 | ALA5120760 | organism-based format | Scientific Literature | |
19. | ALA5121457 | Functional | Antibacterial activity against Micrococcus luteus DSM 1790 assessed as inhibition of bacterial growth incubated for overnight by serial dilution method | Micrococcus luteus | 11 | ALA5120760 | organism-based format | Scientific Literature | |
20. | ALA5121458 | Functional | Antifungal activity against Mucor hiemalis DSM 2656 assessed as inhibition of fungal growth incubated for overnight by serial dilution method | Mucor hiemalis | 12 | ALA5120760 | organism-based format | Scientific Literature |