# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA615542 | F | Insulin-sensitizing activity; triglyceride accumulation from insulin regulated differentiation of 3T3-L1 cells at 1 uM expressed as percent activity of pioglitazone | Mus musculus | 17 | cell-based format | Scientific Literature | ||
2. | ALA615543 | F | Compound was tested for insulin-sensitizing activity by measuring triglyceride accumulation from insulin regulated differentiation of 3T3-L1 cells at 10 uM expressed as percent activity of pioglitazone | Mus musculus | 7 | cell-based format | Scientific Literature | ||
3. | ALA690739 | F | Insulin-releasing activity in HIT-T15 cells in the presence of 16.7 mM glucose at 10 uM expressed as percent activity of nateglinide | Cricetulus griseus | 17 | cell-based format | Scientific Literature | ||
4. | ALA736130 | F | Hypoglycemic activity causing more than a 20% blood glucose decrease in fasting mice | Mus musculus | 15 | organism-based format | Scientific Literature | ||
5. | ALA2071962 | A | Inhibition of human CYP1A2 assessed as ratio of IC50 in absence of NADPH to IC50 for presence of NADPH using ethoxyresorufin as substrate after 30 mins | Homo sapiens | 221 | single protein format | Scientific Literature | ||
6. | ALA2071963 | A | Inhibition of human CYP2C9 assessed as ratio of IC50 in absence of NADPH to IC50 for presence of NADPH using 7-methoxy-4-trifluoromethylcoumarin-3-acetic acid as substrate after 30 mins | Homo sapiens | 221 | single protein format | Scientific Literature | ||
7. | ALA2071964 | A | Inhibition of human CYP2C19 assessed as ratio of IC50 in absence of NADPH to IC50 for presence of NADPH using 3-butyryl-7-methoxycoumarin as substrate after 30 mins | Homo sapiens | 221 | single protein format | Scientific Literature | ||
8. | ALA2071965 | A | Inhibition of human CYP2D6 assessed as ratio of IC50 in absence of NADPH to IC50 for presence of NADPH using 4-methylaminoethyl-7-methoxycoumarin as substrate after 30 mins | Homo sapiens | 221 | single protein format | Scientific Literature | ||
9. | ALA2071966 | A | Inhibition of human CYP3A4 assessed as ratio of IC50 in absence of NADPH to IC50 for presence of NADPH using diethoxyfluorescein as substrate after 30 mins | Homo sapiens | 221 | single protein format | Scientific Literature | ||
10. | ALA2071967 | A | Inhibition of human CYP3A4 assessed as ratio of IC50 in absence of NADPH to IC50 for presence of NADPH using 7-benzyloxyquinoline as substrate after 30 mins | Homo sapiens | 221 | single protein format | Scientific Literature | ||
11. | ALA2071969 | A | Metabolic stability in human liver microsomes assessed as medium signal/noise ratio (S/N of 10 to 100) by measuring GSH adduct formation at 100 uM after 90 mins by HPLC-MS analysis | Homo sapiens | 32 | microsome format | Scientific Literature | ||
12. | ALA2071972 | A | Covalent binding affinity to human liver microsomes assessed per mg of protein at 10 uM after 60 mins presence of NADPH | Homo sapiens | 221 | microsome format | Scientific Literature | ||
13. | ALA2077224 | F | TP_TRANSPORTER: uptake in PEPT2-expressing LLC-PK1 cells | 1 | cell-based format | TP-search Transporter Database | |||
14. | ALA2077252 | F | TP_TRANSPORTER: inhibition of Gly-Sar uptake (Gly-Sar: 20 uM) in PEPT2-expressing LLC-PK1 cells | 1 | cell-based format | TP-search Transporter Database | |||
15. | ALA2076300 | F | TP_TRANSPORTER: inhibition of PAH uptake in Xenopus laevis oocytes | Xenopus laevis | 4 | cell-based format | TP-search Transporter Database | ||
16. | ALA2075919 | F | TP_TRANSPORTER: uptake in Xenopus laevis oocytes | Xenopus laevis | 1 | cell-based format | TP-search Transporter Database | ||
17. | ALA2075921 | F | TP_TRANSPORTER: uptake in PEPT1-expressing LLC-PK1 cells | 1 | cell-based format | TP-search Transporter Database | |||
18. | ALA2075937 | F | TP_TRANSPORTER: inhibition of Gly-Sar uptake (Gly-Sar: 20 uM) in PEPT1-expressing LLC-PK1 cells | 1 | cell-based format | TP-search Transporter Database | |||
19. | ALA2051565 | F | Insulinotropic activity in rat INS1(833/15) cells assessed as increase in insulin secretion at 10 uM after 2 hrs by competitive enzyme immunoassay in the presence of low concentration of glucose | Rattus norvegicus | 1 | cell-based format | Scientific Literature | ||
20. | ALA2051568 | F | Insulinotropic activity in rat INS1(833/15) cells assessed as increase in insulin secretion at 10 uM after 2 hrs by competitive enzyme immunoassay in the presence of 11 mM glucose | Rattus norvegicus | 1 | cell-based format | Scientific Literature |