| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA1020030 | B | Inhibition of human KSP | Homo sapiens | 15 | assay format | Scientific Literature | ||
| 2. | ALA1020031 | F | Ratio of IC50 for induction of mitotic arrest in human KB-3-1 cells expressing MDR1 to IC50 for induction of mitotic arrest in MDRA1 deficient human KB-V-1 cells | Homo sapiens | 10 | cell-based format | Scientific Literature | ||
| 3. | ALA1020032 | P | Dissociation constant, pKa by Sirius GLpKa titrator | 8 | small-molecule physicochemical format | Scientific Literature | |||
| 4. | ALA1020033 | B | Displacement of [35S]MK499 from human ERG expressed in HEL cells | Homo sapiens | 10 | cell-based format | Scientific Literature | ||
| 5. | ALA1020034 | F | Induction of mitotic arrest in human A2780 cells expressing MDR1 after 16 hrs | Homo sapiens | 8 | cell-based format | Scientific Literature | ||
| 6. | ALA1020035 | B | Inhibition of human KSP in presence of 30% mouse serum | Homo sapiens | 4 | assay format | Scientific Literature | ||
| 7. | ALA1020036 | F | Induction of mitotic arrest in human A2780 cells xenografted iv dosed clr:NU/NU-nuBR mouse assessed as minimum plasma concentration required to induce maximum mitotic arrest after 22 hrs | Homo sapiens | 5 | organism-based format | Scientific Literature | ||
| 8. | ALA1020037 | T | Toxicity in naive mouse assessed as neutopenia after 6 days | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 9. | ALA1020038 | F | Inhibition of tumor growth in human A2780 cells xenografted clr:NU/NU-nuBR mouse assessed as change in tumor volume at 100 mg/kg, ip administered q4d x 3 dosing schedule | Homo sapiens | 1 | organism-based format | Scientific Literature | ||
| 10. | ALA1020039 | F | Inhibition of tumor growth in paclitaxel-resistant human PTX10 cells carries tubulin mutation xenografted clr:NU/NU-nuBR mouse assessed as change in tumor volume at 100 mg/kg, ip administered q4d x 3 dosing schedule relative to control | Homo sapiens | 1 | organism-based format | Scientific Literature | ||
| 11. | ALA1020040 | F | Inhibition of tumor growth in human KB-v cells expressing MDR1 xenografted clr:NU/NU-nuBR mouse assessed as change in tumor volume at 100 mg/kg, ip administered q4d x 3 dosing schedule relative to control | Homo sapiens | 1 | organism-based format | Scientific Literature | ||
| 12. | ALA1020041 | B | Selectivity for human KSP over cloned human CENP-E | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 13. | ALA1020042 | B | Selectivity for human KSP over cloned human MKLP1 | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 14. | ALA1020043 | B | Selectivity for human KSP over cloned human Kif3A | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 15. | ALA1020044 | B | Selectivity for human KSP over cloned human Kif1B | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 16. | ALA1020045 | B | Selectivity for human KSP over cloned human uKHC | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 17. | ALA1020046 | B | Selectivity for human KSP over cloned human nKHC | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 18. | ALA1020047 | B | Selectivity for human KSP over cloned human Kif14 | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 19. | ALA1020048 | B | Selectivity for human KSP over cloned human MCAK | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 20. | ALA1020049 | B | Inhibition of cloned human CENP-E | Homo sapiens | 1 | single protein format | Scientific Literature |
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