| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA1023822 | B | Inhibition of humanized rabbit cathepsin K Tyr61Asp and Val157Leu mutant | Homo sapiens | 6 | ALA1140150 | assay format | Scientific Literature | |
| 2. | ALA1023823 | B | Inhibition of rabbit cathepsin K | Oryctolagus cuniculus | 6 | ALA1140150 | single protein format | Scientific Literature | |
| 3. | ALA1023824 | B | Selectivity for rabbit cathepsin K over human cathepsin K | 6 | ALA1140150 | assay format | Scientific Literature | ||
| 4. | ALA1023825 | B | Selectivity for rabbit cathepsin K over human cathepsin B | 6 | ALA1140150 | assay format | Scientific Literature | ||
| 5. | ALA1023826 | B | Selectivity for rabbit cathepsin K over human cathepsin S | 6 | ALA1140150 | assay format | Scientific Literature | ||
| 6. | ALA1023827 | A | Metabolic stability in po dosed rat bile assessed as drug recovery after 96 hrs | Rattus norvegicus | 1 | ALA1140150 | organism-based format | Scientific Literature | |
| 7. | ALA1023828 | A | Metabolic stability in po dosed rat urine assessed as drug recovery after 96 hrs | Rattus norvegicus | 1 | ALA1140150 | organism-based format | Scientific Literature | |
| 8. | ALA1023829 | A | Metabolic stability in po dosed rat feces assessed as drug recovery after 96 hrs | Rattus norvegicus | 1 | ALA1140150 | organism-based format | Scientific Literature | |
| 9. | ALA1023830 | A | Metabolic stability in po dosed rat assessed as drug recovery after 96 hrs | Rattus norvegicus | 1 | ALA1140150 | organism-based format | Scientific Literature | |
| 10. | ALA1023831 | A | Metabolic stability in po dosed rat assessed as (1R,2R)-5,5-dichloro-N-(1-cyanocyclopropyl)-2-(4-(4-(methylsulfonyl)phenyl)-1H-pyrazol-3-yl)cyclohexanecarboxamide level after 96 hrs | Rattus norvegicus | 1 | ALA1140150 | organism-based format | Scientific Literature | |
| 11. | ALA1023832 | F | Inhibition of bone resorption in rabbit bone | Oryctolagus cuniculus | 6 | ALA1140150 | tissue-based format | Scientific Literature | |
| 12. | ALA1023833 | F | Bone resorption shift, ratio of IC50 for inhibition of bone resorption in rabbit bone to IC50 for rabbit cathepsin K | Oryctolagus cuniculus | 6 | ALA1140150 | assay format | Scientific Literature | |
| 13. | ALA1023834 | B | Selectivity for rabbit cathepsin K over human cathepsin C | 2 | ALA1140150 | assay format | Scientific Literature | ||
| 14. | ALA1023835 | B | Selectivity for rabbit cathepsin K over human cathepsin H | 2 | ALA1140150 | assay format | Scientific Literature | ||
| 15. | ALA1023836 | B | Selectivity for rabbit cathepsin K over human cathepsin Z | 2 | ALA1140150 | assay format | Scientific Literature | ||
| 16. | ALA1023837 | B | Selectivity for rabbit cathepsin K over human cathepsin V | 2 | ALA1140150 | assay format | Scientific Literature | ||
| 17. | ALA1023838 | B | Selectivity for rabbit cathepsin K over human cathepsin F | 2 | ALA1140150 | assay format | Scientific Literature | ||
| 18. | ALA1023839 | F | Inhibition of bone resorption in ovariectomized monkey model of osteoporosis assessed as reduction of urinary-N-telopeptide fragment level at 3 mg/kg administered once daily | Macaca mulatta | 1 | ALA1140150 | organism-based format | Scientific Literature | |
| 19. | ALA1023840 | F | Inhibition of bone resorption in rhesus monkey bone | Macaca mulatta | 1 | ALA1140150 | tissue-based format | Scientific Literature | |
| 20. | ALA1023841 | F | Inhibition of bone resorption in ovariectomized monkey model of osteoporosis assessed as reduction of urinary-N-telopeptide fragment level at 1 mg/kg, po qd for 1 week | Macaca mulatta | 1 | ALA1140150 | organism-based format | Scientific Literature |
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