# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3736996 | ADME | Ratio of drug level in tumor to skin in iv dosed BDXI rat implanted with rat LSBD1 cells after 24 hrs | Rattus norvegicus | 1 | ALA3734686 | organism-based format | Scientific Literature | |
2. | ALA4190062 | Physicochemical | Solubility in 25% aqueous ethanolic medium at 25 degC after 24 hrs by UV-VIS spectrometric method | 2 | ALA4184338 | small-molecule physicochemical format | Scientific Literature | ||
3. | ALA4303805 | Functional | Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of Caco-2 cells at 10 uM after 48 hours by high content imaging | Homo sapiens | 5,612 | ALA4303101 | organism-based format | SARS-CoV-2 Screening Data 2020-21 | |
4. | ALA4349522 | Functional | Photodynamic antibacterial activity against Enterococcus faecalis assessed as reduction in bacterial burden at 10 uM in presence of light irradiation at 100 J/cm2 | Enterococcus faecalis | 1 | ALA4346724 | organism-based format | Scientific Literature | |
5. | ALA4349523 | Functional | Photodynamic antibacterial activity against Enterococcus faecalis assessed as reduction in bacterial burden at 30 uM in presence of light irradiation at 100 J/cm2 | Enterococcus faecalis | 1 | ALA4346724 | organism-based format | Scientific Literature | |
6. | ALA4349524 | ADME | Dark toxicity against Enterococcus faecalis assessed as reduction in bacterial burden | Enterococcus faecalis | 1 | ALA4346724 | organism-based format | Scientific Literature | |
7. | ALA4398484 | Toxicity | Dark toxicity in human A549 cells assessed as reduction in cell viability at 0.1 to 0.9 uM after 24 hrs by MTT assay | Homo sapiens | 3 | ALA4396894 | cell-based format | Scientific Literature | |
8. | ALA4398485 | Toxicity | Dark toxicity in human A549 cells xenografted in BALB/c nude mouse assessed as reduction in tumor growth at 0.15 mg/kg, iv measured up to 14 days | Homo sapiens | 3 | ALA4396894 | organism-based format | Scientific Literature | |
9. | ALA4398490 | Functional | Induction of singlet oxygen generation in DMF solution assessed as singlet oxygen quantum yield irradiated with 650 nanometer laser light for 5 to 30 secs measured immediately by DPBF-based assay | 3 | ALA4396894 | assay format | Scientific Literature | ||
10. | ALA4398492 | Functional | Photodynamic cytotoxicity against human A549 cells assessed as reduction in cell viability preincubated for 24 hrs followed by compound washout and subsequent 650 nanometer laser light irradiation at 0.5 J/cm2 measured by MTT assay | Homo sapiens | 3 | ALA4396894 | cell-based format | Scientific Literature | |
11. | ALA4398493 | Functional | Photodynamic cytotoxicity against human A549 cells assessed as reduction in cell viability at 0.1 to 0.9 uM preincubated for 24 hrs followed by compound washout and subsequent 650 nanometer laser light irradiation at 0.5 to 2 J/cm2 measured by MTT assay | Homo sapiens | 1 | ALA4396894 | cell-based format | Scientific Literature | |
12. | ALA4398495 | Functional | Photodynamic cytotoxicity against human A549 cells assessed as reduction in cell viability preincubated for 24 hrs followed by compound washout and subsequent 650 nanometer laser light irradiation at 1 J/cm2 measured by MTT assay | Homo sapiens | 3 | ALA4396894 | cell-based format | Scientific Literature | |
13. | ALA4398496 | Functional | Photodynamic cytotoxicity against human A549 cells assessed as reduction in cell viability preincubated for 24 hrs followed by compound washout and subsequent 650 nanometer laser light irradiation at 2 J/cm2 measured by MTT assay | Homo sapiens | 3 | ALA4396894 | cell-based format | Scientific Literature | |
14. | ALA4398501 | Functional | Photodynamic antitumor activity against human A549 cells xenografted in BALB/c nude mouse assessed as decrease in tumor growth at 0.15 mg/kg, iv irradiated with laser light at 120 J/cm2 measured up to 14 days | Homo sapiens | 3 | ALA4396894 | organism-based format | Scientific Literature | |
15. | ALA4398502 | Functional | Photodynamic antitumor activity against human A549 cells xenografted in BALB/c nude mouse assessed as decrease in tumor weight at 0.15 mg/kg, iv irradiated with laser light at 120 J/cm2 measured 13 days post light irradiation | Homo sapiens | 3 | ALA4396894 | organism-based format | Scientific Literature | |
16. | ALA4495582 | Functional | SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response from peptide substrate | Severe acute respiratory syndrome coronavirus 2 | 7,212 | ALA4495564 | assay format | SARS-CoV-2 Screening Data 2020-21 | |
17. | ALA4513082 | Functional | Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging | Chlorocebus sabaeus | 7,212 | ALA4495565 | organism-based format | SARS-CoV-2 Screening Data 2020-21 | |
18. | ALA4683881 | Toxicity | Dark toxicity in human QBC939 cells assessed as reduction in cell viability incubated under dark for 24 hrs measured after 24 hrs by MTT assay | Homo sapiens | 3 | ALA4680162 | cell-based format | Scientific Literature | |
19. | ALA4683882 | Functional | Phototoxicity against human QBC939 cells assessed as reduction in cell viability irradiated with 1 J/cm2 of 650 nanometer laser light preincubated for 24 hrs in dark and measured after 24 hrs by MTT assay | Homo sapiens | 3 | ALA4680162 | cell-based format | Scientific Literature | |
20. | ALA4683895 | Functional | Phototoxicity against human QBC939 cells assessed as reduction in cell viability irradiated with 2 J/cm2 of 650 nanometer laser light preincubated for 24 hrs in dark and measured after 24 hrs by MTT assay | Homo sapiens | 3 | ALA4680162 | cell-based format | Scientific Literature |