| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA967033 | B | Inhibition of human recombinant cathepsin S by fluorescence assay | Homo sapiens | 8 | single protein format | Scientific Literature | ||
| 2. | ALA967034 | B | Inhibition of human recombinant cathepsin K by fluorescence assay | Homo sapiens | 8 | single protein format | Scientific Literature | ||
| 3. | ALA967035 | B | Inhibition of human recombinant cathepsin L by fluorescence assay | Homo sapiens | 8 | single protein format | Scientific Literature | ||
| 4. | ALA967044 | B | Inhibition of cathepsin S-mediated proteolytic cleavage of MHC2 associated invariant chain in mouse splenocytes assessed as induction of accumulation of lip10 | Mus musculus | 2 | cell-based format | Scientific Literature | ||
| 5. | ALA967046 | A | Plasma clearance in Sprague-Dawley rat at 1 mg/kg, iv and 3 mg/kg, po by LC/MS analysis | Rattus norvegicus | 3 | organism-based format | Scientific Literature | ||
| 6. | ALA967047 | A | Terminal elimination half life in Sprague-Dawley rat at 1 mg/kg, iv by LC/MS analysis | Rattus norvegicus | 3 | organism-based format | Scientific Literature | ||
| 7. | ALA967048 | A | Bioavailability in Sprague-Dawley rat at 1 mg/kg, iv and 3 mg/kg, po by LC/MS analysis | Rattus norvegicus | 3 | organism-based format | Scientific Literature | ||
| 8. | ALA967049 | A | Normalized AUC (infinity) in Sprague-Dawley rat at 3 mg/kg, po by LC/MS analysis | Rattus norvegicus | 3 | organism-based format | Scientific Literature | ||
| 9. | ALA967050 | A | Cmax in Sprague-Dawley rat at 3 mg/kg, po by LC/MS analysis | Rattus norvegicus | 3 | organism-based format | Scientific Literature | ||
| 10. | ALA967051 | A | Volume of distribution in Sprague-Dawley rat at 1 mg/kg, iv and 3 mg/kg, po by LC/MS analysis | Rattus norvegicus | 3 | organism-based format | Scientific Literature | ||
| 11. | ALA967052 | B | Inhibition of rat cathepsin S glycine 137 mutant by fluorescence assay | Rattus norvegicus | 3 | assay format | Scientific Literature | ||
| 12. | ALA967053 | B | Inhibition of rat cathepsin S cysteine 137 mutant by fluorescence assay | Rattus norvegicus | 3 | assay format | Scientific Literature | ||
| 13. | ALA967054 | B | Inhibition of rat cathepsin K by fluorescence assay | Rattus norvegicus | 3 | single protein format | Scientific Literature | ||
| 14. | ALA967055 | B | Inhibition of rat cathepsin L by fluorescence assay | Rattus norvegicus | 3 | single protein format | Scientific Literature | ||
| 15. | ALA967056 | B | Inhibition of mouse cathepsin S by fluorescence assay | Mus musculus | 3 | single protein format | Scientific Literature | ||
| 16. | ALA967057 | B | Selectivity for rat cathepsin S glycine 137 mutant over rat cathepsin K | Rattus norvegicus | 8 | assay format | Scientific Literature | ||
| 17. | ALA967058 | B | Selectivity for rat cathepsin S glycine 137 mutant over rat cathepsin L | Rattus norvegicus | 8 | assay format | Scientific Literature | ||
| 18. | ALA967059 | B | Selectivity for rat cathepsin S glycine 137 mutant over rat cathepsin B | Rattus norvegicus | 8 | assay format | Scientific Literature | ||
| 19. | ALA969766 | F | Reversal of neuropathic mechanical hyperalgesia in Wistar rat sciatic nerve ligation model assessed as paw withdrawal threshold at 30 mg/kg, po administered twice daily for 5 days after 3 hrs | Rattus norvegicus | 2 | organism-based format | Scientific Literature | ||
| 20. | ALA969767 | A | Inhibition of CYP1A2 at 10 uM | 2 | single protein format | Scientific Literature |
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