# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA1832105 | B | Inhibition of human recombinant DAAO expressed in Escherichia coli assessed as H2O2 production from D-serine degradation after 30 mins by fluorescence assay | Homo sapiens | 6 | assay format | Scientific Literature | ||
2. | ALA1832107 | B | Binding affinity to human recombinant DAAO by isothermal titration calorimeter analysis | Homo sapiens | 6 | single protein format | Scientific Literature | ||
3. | ALA1832108 | B | Binding affinity to human recombinant DAAO by kinetic study scintillation proximity assay | Homo sapiens | 6 | single protein format | Scientific Literature | ||
4. | ALA1832109 | B | Binding affinity to human recombinant DAAO by steady state study scintillation proximity assay | Homo sapiens | 6 | single protein format | Scientific Literature | ||
5. | ALA1832110 | B | Inhibition of bovine recombinant DASPO expressed in Escherichia coli preincubated for 15 mins by fluorescence assay | Bos taurus | 6 | assay format | Scientific Literature | ||
6. | ALA1832111 | B | Inhibition of human ERG expressed in HEK293 cells by whole cell voltage patch clamp technique | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
7. | ALA1832112 | B | Binding affinity to human recombinant DAAO assessed as drug-enzyme complex half life | Homo sapiens | 6 | single protein format | Scientific Literature | ||
8. | ALA1832113 | P | Dissociation constant, pKa of the compound by dip probe absorption spectroscopy technique | 6 | small-molecule physicochemical format | Scientific Literature | |||
9. | ALA1832114 | P | Octanol-water partition coefficient, log P of the neutral compound by pH-metric method | 6 | small-molecule physicochemical format | Scientific Literature | |||
10. | ALA1832115 | P | Octanol-water partition coefficient, log P of the anionic compound by pH-metric method | 3 | small-molecule physicochemical format | Scientific Literature | |||
11. | ALA1832116 | P | Thermodynamic solubility of the compound in phosphate buffer at pH 7.4 after 24 hrs by HPLC analysis | 6 | small-molecule physicochemical format | Scientific Literature | |||
12. | ALA1832117 | P | Kinetic solubility of the compound in 0.01 M phosphate buffered saline at pH 7.4 assessed as minimum solubility after 2 hrs | 6 | small-molecule physicochemical format | Scientific Literature | |||
13. | ALA1832118 | P | Kinetic solubility of the compound in 0.01 M phosphate buffered saline at pH 7.4 assessed as maximum solubility after 2 hrs | 6 | small-molecule physicochemical format | Scientific Literature | |||
14. | ALA1832265 | A | Intrinsic clearance in human liver microsomes | Homo sapiens | 3 | microsome format | Scientific Literature | ||
15. | ALA1832267 | A | Cmax in Wistar rat brain at 10 mg/kg, po | Rattus norvegicus | 5 | organism-based format | Scientific Literature | ||
16. | ALA1832269 | A | Cmax in Swiss mouse brain at 10 mg/kg, po | Mus musculus | 5 | organism-based format | Scientific Literature | ||
17. | ALA1832271 | A | AUC (0 to last) in Wistar rat brain at 10 mg/kg, po | Rattus norvegicus | 5 | organism-based format | Scientific Literature | ||
18. | ALA1832273 | A | AUC (0 to last) in Swiss mouse brain at 10 mg/kg, po | Mus musculus | 5 | organism-based format | Scientific Literature | ||
19. | ALA1832275 | A | Ratio of drug level (0 to last) in brain to plasma in Wistar rat at 10 mg/kg, po | Rattus norvegicus | 5 | organism-based format | Scientific Literature | ||
20. | ALA1832277 | A | Ratio of drug level (0 to last) in brain to plasma in Swiss mouse at 10 mg/kg, po | Mus musculus | 5 | organism-based format | Scientific Literature |