# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA1653933 | Functional | Antiparasitic activity against Trypanosoma brucei rhodesiense STIB 900 clone after 72 hrs by Alamar blue assay | Trypanosoma brucei rhodesiense | 5 | ALA1649443 | organism-based format | Scientific Literature | |
2. | ALA1653934 | Binding | Ratio of Kinact to Kiapp for Trypanosoma brucei AdoMetDC expressed in Escherichia coli | Trypanosoma brucei | 5 | ALA1649443 | assay format | Scientific Literature | |
3. | ALA1653935 | Binding | Ratio of Kinact to Kiapp for human AdoMetDC expressed in Escherichia coli | Homo sapiens | 5 | ALA1649443 | assay format | Scientific Literature | |
4. | ALA1653936 | Physicochemical | Kinetic solubility in dimethyl sulfoxide at pH 7.4 after 16 to 24 hrs by UV spectrophotometry | 5 | ALA1649443 | small-molecule physicochemical format | Scientific Literature | ||
5. | ALA1653937 | ADME | Permeability of the compound after 4 hrs by PAMPA assay | 5 | ALA1649443 | assay format | Scientific Literature | ||
6. | ALA1653938 | ADME | Metabolic stability in rat liver microsomes assessed as intrinsic clearance up to 45 mins by LC/MS/MS analysis | Rattus norvegicus | 5 | ALA1649443 | microsome format | Scientific Literature | |
7. | ALA1653939 | ADME | Metabolic stability in human liver microsomes assessed as intrinsic clearance up to 45 mins by LC/MS/MS analysis | Homo sapiens | 5 | ALA1649443 | microsome format | Scientific Literature | |
8. | ALA1653940 | ADME | Metabolic stability in rat hepatocytes assessed as intrinsic clearance up to 45 mins by LC/MS/MS analysis | Rattus norvegicus | 5 | ALA1649443 | cell-based format | Scientific Literature | |
9. | ALA1653941 | ADME | Metabolic stability in human hepatocytes assessed as intrinsic clearance up to 45 mins by LC/MS/MS analysis | Homo sapiens | 5 | ALA1649443 | cell-based format | Scientific Literature | |
10. | ALA1653942 | ADME | Inhibition of human cytochrome P450 3A4 | Homo sapiens | 5 | ALA1649443 | single protein format | Scientific Literature | |
11. | ALA1653943 | ADME | Inhibition of human cytochrome P450 2D6 | Homo sapiens | 5 | ALA1649443 | single protein format | Scientific Literature | |
12. | ALA1653944 | ADME | Inhibition of human cytochrome P450 2C9 | Homo sapiens | 5 | ALA1649443 | single protein format | Scientific Literature | |
13. | ALA1653945 | ADME | Inhibition of human cytochrome P450 2C19 | Homo sapiens | 5 | ALA1649443 | single protein format | Scientific Literature | |
14. | ALA1653946 | ADME | Inhibition of human cytochrome P450 1A2 | Homo sapiens | 5 | ALA1649443 | single protein format | Scientific Literature | |
15. | ALA1653947 | ADME | Protein binding in human plasma at pH 7.4 after 4 hrs | Homo sapiens | 5 | ALA1649443 | cell-free format | Scientific Literature | |
16. | ALA1653948 | ADME | Protein binding in mouse plasma at pH 7.4 after 4 hrs | Mus musculus | 5 | ALA1649443 | cell-free format | Scientific Literature | |
17. | ALA971399 | Binding | Inhibition of Trypanosoma brucei AdoMetDC assessed as ratio of Kinact to Ki(apparent) | Trypanosoma brucei | 5 | ALA1136916 | assay format | Scientific Literature | |
18. | ALA971400 | Functional | Antitrypanosomal activity against Trypanosoma brucei rhodesiense | Trypanosoma brucei rhodesiense | 8 | ALA1136916 | organism-based format | Scientific Literature | |
19. | ALA971401 | Functional | Antitrypanosomal activity against Trypanosoma brucei brucei | Trypanosoma brucei brucei | 8 | ALA1136916 | organism-based format | Scientific Literature |