# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA1930044 | P | Dissociation constant, pKa of the compound | 5 | small-molecule physicochemical format | Scientific Literature | |||
2. | ALA974339 | B | Inhibition of MMP13 | 64 | single protein format | Scientific Literature | |||
3. | ALA974340 | B | Inhibition of MMP13 in presence of 1% bovine serum albumin | 64 | single protein format | Scientific Literature | |||
4. | ALA974341 | B | Inhibition of MMP1 | 54 | single protein format | Scientific Literature | |||
5. | ALA974342 | B | Selectivity ratio of IC50 for MMP1 to IC50 for MMP13 | 3 | assay format | Scientific Literature | |||
6. | ALA974344 | F | Inhibition of MMP13-induced cartilage degradation in rat assessed as chondroitin sulfate release at 30 mg/kg, po administered 4 hrs before MMP13 challenge injected intra-articularly measured after 2 hrs by ELISA | Rattus norvegicus | 34 | organism-based format | Scientific Literature | ||
7. | ALA974345 | B | Inhibition of MMP13-mediated type 2 collagen degradation in bovine nasal cartilage assessed as inhibition of IL1/oncostatin M-stimulated N-hydroxyproline release at 200 nM treated for 5 to 6 days measured on day 11 | Bos taurus | 1 | tissue-based format | Scientific Literature | ||
8. | ALA974346 | B | Inhibition of MMP13-mediated type 2 collagen degradation in bovine nasal cartilage assessed as inhibition of IL1/oncostatin M-stimulated N-hydroxyproline release at 2000 nM treated for 5 to 6 days measured on day 11 | Bos taurus | 1 | single protein format | Scientific Literature | ||
9. | ALA974347 | F | Inhibition of MMP13-induced cartilage degradation in rat assessed as chondroitin sulfate release at 10 mg/kg, po administered 4 hrs before MMP13 challenge injected intra-articularly measured after 2 hrs by ELISA | Rattus norvegicus | 2 | organism-based format | Scientific Literature | ||
10. | ALA974348 | B | Inhibition of MMP2 | 2 | single protein format | Scientific Literature | |||
11. | ALA974349 | B | Inhibition of MMP3 | 4 | single protein format | Scientific Literature | |||
12. | ALA974350 | B | Inhibition of MMP7 | 4 | single protein format | Scientific Literature | |||
13. | ALA974351 | B | Inhibition of MMP9 | 4 | single protein format | Scientific Literature | |||
14. | ALA974352 | B | Inhibition of MMP14 | 4 | single protein format | Scientific Literature | |||
15. | ALA974353 | B | Inhibition of TACE | 4 | single protein format | Scientific Literature | |||
16. | ALA974354 | A | Cmax in Sprague-Dawley rat at 10 mg/kg, po | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
17. | ALA974355 | A | Tmax in Sprague-Dawley rat at 10 mg/kg, po | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
18. | ALA974356 | A | Terminal half life in Sprague-Dawley rat at 3 mg/kg, iv | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
19. | ALA974357 | A | Clearance in Sprague-Dawley rat at 3 mg/kg, iv | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
20. | ALA974358 | A | Volume of distribution at steady state in Sprague-Dawley rat at 10 mg/kg, po and 3 mg/kg, iv | Rattus norvegicus | 1 | organism-based format | Scientific Literature |