Phototoxicity in ICR mouse assessed as change in auricles 0.45 mg/kg, iv in presence of 10 mW/cm2 light irradiation for 10 mins upto 7 days measured after 1day of light irradiation by H and E staining based microscopic analysis
Phototoxicity in ICR mouse assessed as ear weight at 0.45 mg/kg, iv followed by 10 mW/cm2 light irradiation for 10 mins at 7 days after drug challenge measured after 1 day of light irradiation (13.2 +/- 1.6 mg)
Phototoxicity in ICR mouse assessed as ear weight at 0.45 mg/kg, iv followed by 10 mW/cm2 light irradiation for 10 mins at 5 days after drug challenge measured after 1 day of light irradiation (Rvb = 12.9 +/- 1.4 mg)
Phototoxicity in ICR mouse assessed as ear weight at 0.45 mg/kg, iv followed by 10 mW/cm2 light irradiation for 10 mins at 3 days after drug challenge measured after 1 day of light irradiation (Rvb = 12.8 +/- 1.5 mg)
Phototoxicity in ICR mouse assessed as ear weight at 0.45 mg/kg, iv followed by 10 mW/cm2 light irradiation for 10 mins at 1 day after drug challenge measured after 1 day of light irradiation (Rvb = 12.6 +/- 1.2 mg)
Induction of ROS generation in DMF solution assessed as slope of the photodegradation rate of DPBF at 2 uM followed by irradiation measured every 10 secs by spectrophotometric analysis
Phototoxicity in ICR mouse assessed as change in exposed neck skin 0.45 mg/kg, iv in presence of 10 mW/cm2 light irradiation for 10 mins upto 7 days measured after 1day of light irradiation by H and E staining based microscopic analysis
Phototoxicity in guinea pig assessed as change in left ear weight 4.5 mg/kg, iv followed by 10 mW/cm2 light irradiation for 10 mins measured after 1 day of light irradiation (Rvb = 39.2 +/- 1.8 mg)
Phototoxicity in guinea pig assessed as change in right ear weight 4.5 mg/kg, iv followed by 10 mW/cm2 light irradiation for 10 mins measured after 1 day of light irradiation (Rvb = 40.4 +/- 2.4 mg)
Phototoxicity in guinea pig assessed as change in back skin weight 4.5 mg/kg, iv followed by 10 mW/cm2 light irradiation for 10 mins measured after 1day of light irradiation (Rvb = 72.4 +/- 3.1 mg)
Phototoxicity in guinea pig assessed as change in auricles of left ear at 4.5 mg/kg, iv in presence of 10 mW/cm2 light irradiation for 10 mins measured after 1day of light irradiation by H and E staining based microscopic analysis
Phototoxicity in guinea pig assessed as change in back skin at 4.5 mg/kg, iv in presence of 10 mW/cm2 light irradiation for 10 mins measured after 1day of light irradiation by H and E staining based microscopic analysis
Induction of ROS generation in DMF solution assessed as ROS quantum yield at 2 uM followed by irradiation measured every 10 secs by spectrophotometric analysis