| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA958953 | B | Inhibition of human DAO | Homo sapiens | 25 | single protein format | Scientific Literature | ||
| 2. | ALA958954 | B | Inhibition of human DDO | Homo sapiens | 5 | single protein format | Scientific Literature | ||
| 3. | ALA2378317 | B | Inhibition of DAAO in Sprague-Dawley lactating rat hypothalamus assessed as reduction in AMPA/NMDA ratio of excitatory postsynaptic currents in supraoptic nucleus neurons at 10 uM after 45 mins by whole-cell patch clamp assay (Rvb = 4.08 +/- 0.41) | Rattus norvegicus | 1 | tissue-based format | Scientific Literature | ||
| 4. | ALA2378318 | B | Binding affinity to human recombinant DAAO at 520 nm spectral modification by stopped flow spectrophotometric analysis in presence of FAD | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 5. | ALA2378326 | B | Binding affinity to human recombinant DAAO at 520 nm spectral modification by spectrophotometric analysis in presence of FAD | Homo sapiens | 2 | single protein format | Scientific Literature | ||
| 6. | ALA2378328 | B | Binding affinity to human recombinant DAAO at 490 nm spectral modification by spectrophotometric analysis in presence of FAD | Homo sapiens | 2 | single protein format | Scientific Literature | ||
| 7. | ALA2378330 | B | Inhibition of DAAO in Sprague-Dawley virgin rat hypothalamus assessed as change in AMPA/NMDA ratio of excitatory postsynaptic currents in supraoptic nucleus neurons at 10 uM after 45 mins by whole-cell patch clamp assay (Rvb = 1.12 +/- 0.23) | Rattus norvegicus | 1 | tissue-based format | Scientific Literature | ||
| 8. | ALA2378331 | F | Inhibition of DAAO in Sprague-Dawley rat assessed as reversal of L701324-induced falling behavior at 125 mg/kg, ip administered for 6 hrs prior to L701324-challenge measured after 6 hrs in presence of D-serine | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 9. | ALA2378332 | F | Inhibition of DAAO in Sprague-Dawley rat assessed as reversal of L701324-induced falling behavior at 125 mg/kg, ip administered for 6 hrs prior to L701324-challenge measured after 6 hrs | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 10. | ALA2378333 | F | Inhibition of DAAO in Sprague-Dawley rat assessed as increase in extracellular D-serine concentration in hippocampus at 125 mg/kg, ip by microdialysis analysis | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 11. | ALA2378334 | F | Inhibition of DAAO in Sprague-Dawley rat assessed as increase in D-serine concentration in hippocampus at 125 mg/kg, ip by microdialysis analysis | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 12. | ALA2378369 | F | Inhibition of DAAO in Sprague-Dawley rat assessed as increase in extracellular D-serine concentration in cerebellum at 125 mg/kg, ip by microdialysis analysis | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 13. | ALA2378370 | F | Inhibition of DAAO in ip dosed Sprague-Dawley rat assessed as cerebellum concentration of compound required for 50% accumulation of D-serine after 6 hrs by LC/MS/MS analysis | Rattus norvegicus | 3 | organism-based format | Scientific Literature | ||
| 14. | ALA2378371 | F | Inhibition of DAAO in Sprague-Dawley rat assessed as change in D-serine concentration in cerebellum at 3 to 10 mg/kg, ip after 4 hrs by LC/MS/MS analysis | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 15. | ALA2378372 | A | Metabolic stability in Sprague-Dawley rat at 3 to 10 mg/kg, po/10 mg/kg, ip by LC/MS/MS analysis | Rattus norvegicus | 2 | organism-based format | Scientific Literature | ||
| 16. | ALA2378373 | F | Inhibition of DAAO in Sprague-Dawley rat assessed as change in D-serine concentration in cerebellum at 125 mg/kg, ip after 18 to 48 hrs by LC/MS/MS analysis | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 17. | ALA2378374 | F | Inhibition of DAAO in Sprague-Dawley rat assessed as increase in D-serine concentration in cerebellum at 125 mg/kg, ip after 12 hrs by LC/MS/MS analysis | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 18. | ALA2378375 | A | Drug uptake in C57BL/6 mouse cerebellum at 30 mg/kg, ip after 6 hrs by LC/MS/MS analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 19. | ALA2378380 | F | Inhibition of DAAO in C57BL/6 mouse assessed as increase in rate of D-serine accumulation in cerebellum at 30 mg/kg, ip after 6 hrs by LC/MS/MS analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 20. | ALA2378382 | B | Competitive inhibition of human recombinant DAAO by Michaelis-Menten plot analysis in presence of D-serine | Homo sapiens | 6 | single protein format | Scientific Literature |
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