# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA973312 | B | Displacement of [125I]NDP-MSH from human MC4R expressed in HEK293 cells | Homo sapiens | 28 | cell-based format | Scientific Literature | ||
2. | ALA976122 | F | Antagonist activity at human MC4R expressed in CHO cells assessed as inhibition of alpha-MSH-induced cAMP production by ELISA | Homo sapiens | 28 | cell-based format | Scientific Literature | ||
3. | ALA976123 | F | Activity at human MC4R expressed in CHO cells assessed as stimulation of alpha-MSH-induced cAMP production at 10 uM by ELISA | Homo sapiens | 20 | cell-based format | Scientific Literature | ||
4. | ALA976124 | B | Selectivity for human MC4R over human MC3R | Homo sapiens | 1 | assay format | Scientific Literature | ||
5. | ALA963789 | B | Displacement of [125I]NDP-MSH from human MC1R expressed in HEK293 cells at 10 uM | Homo sapiens | 10 | cell-based format | Scientific Literature | ||
6. | ALA963790 | B | Displacement of [125I]NDP-MSH from human MC3R expressed in HEK293 cells | Homo sapiens | 12 | cell-based format | Scientific Literature | ||
7. | ALA963791 | B | Displacement of [125I]NDP-MSH from human MC5R expressed in HEK293 cells | Homo sapiens | 12 | cell-based format | Scientific Literature | ||
8. | ALA963792 | B | Inhibition of ghrelin receptor | 2 | single protein format | Scientific Literature | |||
9. | ALA963793 | F | Activation at ghrelin receptor at 10 uM by calcium flux assay | 1 | single protein format | Scientific Literature | |||
10. | ALA963794 | B | Selectivity for human MC4R over ghrelin receptor | 2 | assay format | Scientific Literature | |||
11. | ALA963795 | P | Lipophilicity log D at pH 7.4 by shake-flask method | 20 | small-molecule physicochemical format | Scientific Literature | |||
12. | ALA963797 | A | Apparent permeability across human Caco-2 cells | Homo sapiens | 20 | cell-based format | Scientific Literature | ||
13. | ALA963798 | A | Ratio of permeability from basolateral to apical side over apical to basolateral side of human Caco-2 cells | Homo sapiens | 20 | cell-based format | Scientific Literature | ||
14. | ALA963799 | A | Metabolic stability in human liver microsomes | Homo sapiens | 20 | microsome format | Scientific Literature | ||
15. | ALA963800 | A | Clearance in mouse at 5 mg/kg, iv and 10 mg/kg, po | Mus musculus | 14 | organism-based format | Scientific Literature | ||
16. | ALA963801 | A | Volume of distribution in mouse at 5 mg/kg, iv and 10 mg/kg, po | Mus musculus | 14 | organism-based format | Scientific Literature | ||
17. | ALA963802 | A | Half life in mouse at 5 mg/kg, iv and 10 mg/kg, po | Mus musculus | 14 | organism-based format | Scientific Literature | ||
18. | ALA963803 | A | Drug level in mouse brain at 5 mg/kg, iv after 1 hr | Mus musculus | 13 | organism-based format | Scientific Literature | ||
19. | ALA963804 | A | Drug level in mouse brain at 5 mg/kg, iv after 4 hrs | Mus musculus | 13 | organism-based format | Scientific Literature | ||
20. | ALA964829 | A | Ratio of drug level in brain to plasma in mouse at 5 mg/kg, iv after 1 hr | Mus musculus | 14 | organism-based format | Scientific Literature |