| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA1049568 | Functional | Antitumor initiating activity in human Chang cells assessed as ratio of inhibition of cellular transformation in presence of NOR1 to compound and NOR1 at 350 nmol treated 1 min before NOR1 addition measured after 1 hr by light microscopy | Homo sapiens | 27 | ALA1152514 | cell-based format | Scientific Literature | |
| 2. | ALA998585 | Binding | Channel opening activity at human BKalpha channel expressed in CHOK1 cells assessed as ionic current amplitude at 30 uM at holding potential of -90 mV by population patch clamp technique relative to untreated control | Homo sapiens | 49 | ALA1141715 | cell-based format | Scientific Literature | |
| 3. | ALA974117 | Binding | Inhibition of 12-O-tetradecanoylphorbol 13-acetate-induced Epstein-Barr virus early antigen activation in human Raji cells assessed as EA induction at 1000 mol ratio relative to TPA | Human gammaherpesvirus 4 | 11 | ALA1142631 | cell-based format | Scientific Literature | |
| 4. | ALA974118 | Binding | Inhibition of 12-O-tetradecanoylphorbol 13-acetate-induced Epstein-Barr virus early antigen activation in human Raji cells assessed as EA induction at 500 mol ratio relative to TPA | Human gammaherpesvirus 4 | 11 | ALA1142631 | cell-based format | Scientific Literature | |
| 5. | ALA974119 | Binding | Inhibition of 12-O-tetradecanoylphorbol 13-acetate-induced Epstein-Barr virus early antigen activation in human Raji cells assessed as EA induction at 100 mol ratio relative to TPA | Human gammaherpesvirus 4 | 11 | ALA1142631 | cell-based format | Scientific Literature | |
| 6. | ALA974120 | Binding | Inhibition of 12-O-tetradecanoylphorbol 13-acetate-induced Epstein-Barr virus early antigen activation in human Raji cells assessed as EA induction at 10 mol ratio relative to TPA | Human gammaherpesvirus 4 | 11 | ALA1142631 | cell-based format | Scientific Literature | |
| 7. | ALA974121 | ADME | Cytotoxicity against human Raji cells assessed as cell viability at 1000 molar ratio/TPA | Homo sapiens | 11 | ALA1142631 | cell-based format | Scientific Literature | |
| 8. | ALA1074802 | Functional | Antiproliferative activity against human QGY7703 cells | Homo sapiens | 55 | ALA1157733 | cell-based format | Scientific Literature | |
| 9. | ALA1074803 | Functional | Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO release | Mus musculus | 54 | ALA1157733 | cell-based format | Scientific Literature | |
| 10. | ALA1074804 | Binding | Inhibition of TNF-alpha-induced NF-kappaB activity in human pNF-kappaB-luc-293 cells | Homo sapiens | 53 | ALA1157733 | cell-based format | Scientific Literature | |
| 11. | ALA1074805 | Functional | Antiproliferative activity against human LoVo cells | Homo sapiens | 55 | ALA1157733 | cell-based format | Scientific Literature | |
| 12. | ALA4321074 | Binding | Modulation of recombinant wild type GABAA receptor alpha1beta2gamma2S (unknown origin) expressed in Xenopus laevis oocytes assessed as increase in GABA-evoked chloride current at 10 uM at -70 mV holding potential by two-microelectrode voltage clamp assay relative to control | Homo sapiens | 10 | ALA4316610 | cell-based format | Scientific Literature | |
| 13. | ALA4321075 | Binding | Modulation of recombinant wild type GABAA receptor alpha1beta2gamma2S (unknown origin) expressed in Xenopus laevis oocytes assessed as increase in GABA-evoked chloride current at 100 uM at -70 mV holding potential by two-microelectrode voltage clamp assay relative to control | Homo sapiens | 10 | ALA4316610 | cell-based format | Scientific Literature | |
| 14. | ALA4321076 | ADME | Cytotoxicity against mouse J774 cells assessed as reduction in cell viability after 48 hrs by resazurin dye-based fluorometric analysis | Mus musculus | 10 | ALA4316610 | cell-based format | Scientific Literature | |
| 15. | ALA4321077 | Functional | Antileishmanial activity against Leishmania amazonensis MHOM/Br/79/Mari promastigotes after 48 hrs by resazurin dye-based fluorometric analysis | Leishmania amazonensis | 10 | ALA4316610 | organism-based format | Scientific Literature | |
| 16. | ALA4321078 | Functional | Antileishmanial activity against Leishmania guyanensis 141/93 promastigotes after 48 hrs by resazurin dye-based fluorometric analysis | Leishmania guyanensis | 10 | ALA4316610 | organism-based format | Scientific Literature | |
| 17. | ALA4321079 | Functional | Antileishmanial activity against Leishmania donovani MHOM/IN/80/DD8 promastigotes after 48 hrs by resazurin dye-based fluorometric analysis | Leishmania donovani | 10 | ALA4316610 | organism-based format | Scientific Literature | |
| 18. | ALA4321080 | Functional | Antileishmanial activity against Leishmania infantum MCAN/ES/96/BCN150 promastigotes after 48 hrs by resazurin dye-based fluorometric analysis | Leishmania infantum | 10 | ALA4316610 | organism-based format | Scientific Literature | |
| 19. | ALA4321081 | Toxicity | Selectivity index, ratio of CC50 for mouse J774 cells to IC50 for Leishmania amazonensis MHOM/Br/79/Mari promastigotes | 8 | ALA4316610 | assay format | Scientific Literature | ||
| 20. | ALA4321082 | Toxicity | Selectivity index, ratio of CC50 for mouse J774 cells to IC50 for Leishmania guyanensis 141/93 promastigotes | 8 | ALA4316610 | assay format | Scientific Literature |
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