# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4136096 | Functional | Bactericidal activity against Escherichia coli ATCC 25922 at 12 after 6 hrs by time kill assay | Escherichia coli | 1 | ALA4130549 | organism-based format | Scientific Literature | |
2. | ALA4368675 | Functional | Antimicrobial activity against Listeria monocytogenes clinical isolate at 30 ug/disk incubated for 20 +/- 4 hrs by agar disk diffusion method | Listeria monocytogenes | 1 | ALA4364345 | organism-based format | Scientific Literature | |
3. | ALA4416284 | Binding | Binding affinity to bacterial Beta-lactamase TEM-1 M182T mutant assessed as change in melting temperature at 100-fold molar excess compound concentration relative to apo-enzymes by SYPRO Orange dye based differential scanning fluorimetry | Bacteria | 1 | ALA4414607 | assay format | Scientific Literature | |
4. | ALA4416285 | Binding | Binding affinity to bacterial Beta-lactamase TEM-1 M182T/G238S mutant assessed as change in melting temperature at 100-fold molar excess compound concentration relative to apo-enzymes by SYPRO Orange dye based differential scanning fluorimetry | Bacteria | 1 | ALA4414607 | assay format | Scientific Literature | |
5. | ALA4416286 | Binding | Binding affinity to bacterial wild type Beta-lactamase TEM-1 assessed as change in melting temperature at 100-fold molar excess compound concentration relative to apo-enzymes by SYPRO Orange dye based differential scanning fluorimetry | Bacteria | 1 | ALA4414607 | single protein format | Scientific Literature | |
6. | ALA4416287 | Binding | Binding affinity to bacterial Beta-lactamase TEM-1 R164S mutant assessed as change in melting temperature at 100-fold molar excess compound concentration relative to apo-enzymes by SYPRO Orange dye based differential scanning fluorimetry | Bacteria | 1 | ALA4414607 | assay format | Scientific Literature | |
7. | ALA4416288 | Binding | Binding affinity to bacterial Beta-lactamase TEM-1 G238S mutant assessed as change in melting temperature at 100-fold molar excess compound concentration relative to apo-enzymes by SYPRO Orange dye based differential scanning fluorimetry | Bacteria | 1 | ALA4414607 | assay format | Scientific Literature | |
8. | ALA4416289 | Binding | Binding affinity to bacterial Beta-lactamase TEM-1 D179G mutant assessed as change in melting temperature at 100-fold molar excess compound concentration relative to apo-enzymes by SYPRO Orange dye based differential scanning fluorimetry | Bacteria | 1 | ALA4414607 | assay format | Scientific Literature | |
9. | ALA4674728 | Functional | Bactericidal activity against early exponential phase of Escherichia coli ATCC 25922 at 6X MIC measured after 6 hrs by time-kill kinetic assay | Escherichia coli | 1 | ALA4673214 | organism-based format | Scientific Literature |