| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA2038585 | B | Inhibition of human recombinant AKR1C2 expressed in Escherichia coli using S-tetralol as substrate by fluorometry | Homo sapiens | 3 | assay format | Scientific Literature | ||
| 2. | ALA2038586 | B | Inhibition of human recombinant AKR1C3 expressed in Escherichia coli JM109 cells using S-tetralol as substrate by fluorometry | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
| 3. | ALA2038588 | B | Inhibition of human recombinant GST-tagged AKR1C1 expressed in Escherichia coli using S-tetralol as substrate at 100 uM by fluorometry | Homo sapiens | 5 | assay format | Scientific Literature | ||
| 4. | ALA2038591 | B | Inhibition of human recombinant GST-tagged AKR1C4 expressed in Escherichia coli using S-tetralol as substrate at 100 uM by fluorometry | Homo sapiens | 5 | assay format | Scientific Literature | ||
| 5. | ALA2038686 | F | Cytotoxicity against human MCF7 cells at <100 uM after 6 hrs by MTT assay | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 6. | ALA2038688 | B | Inhibition of AKR1C3-mediated [14C]farnesal metabolism in human MCF7 cells at 100 uM incubated for 2 hrs prior to substrate addition measured after 6 hrs | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 7. | ALA1820939 | F | Cytotoxicity against human HCT116 cells assessed as cell viability under hypoxic condition at 200 uM after 24 hrs by MTT assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 8. | ALA1820941 | B | Modulation of HIF1 expressed in HEK293 cells assessed as luciferase activity under hypoxic condition at 50 uM after 24 hrs by luminometer analysis relative to hypoxic control | 9 | cell-based format | Scientific Literature | |||
| 9. | ALA1820942 | F | Cytotoxicity against human HCT116 cells assessed as cell viability under normoxic condition at 200 uM after 24 hrs by MTT assay | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 10. | ALA1820943 | F | Cytotoxicity against human HCT116 cells assessed as cell viability under hypoxic condition at 200 uM after 7 days by clonogenic assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 11. | ALA1820944 | F | Cytotoxicity against human HCT116 cells assessed as cell viability under normoxic condition at 200 uM after 7 days by clonogenic assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 12. | ALA1820951 | B | Modulation of HIF1 expressed in HEK293 cells assessed as luciferase activity under hypoxic condition after 24 hrs by luminometer analysis | 4 | cell-based format | Scientific Literature | |||
| 13. | ALA1820953 | F | Inhibition of HIF1alpha expression in human HCT116 cells under hypoxic condition after 4 hrs by immunoblotting | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 14. | ALA1820954 | B | Inhibition of HIF1-dependent GLUT1 mRNA expression in human HCT116 cells under hypoxic condition at 50 uM after 24 hrs by RT-PCR analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 15. | ALA1820955 | B | Inhibition of HIF1-dependent HK2 mRNA expression in human HCT116 cells under hypoxic condition at 50 uM after 24 hrs by RT-PCR analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 16. | ALA1820956 | B | Inhibition of HIF1-dependent VEGFA mRNA expression in human HCT116 cells under hypoxic condition at 50 uM after 24 hrs by RT-PCR analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 17. | ALA1821001 | F | Antiangiogenic activity in 3-day-old embryonated chicken eggs at 300 ng/CAM measured on 7th embryonic day by CAM assay | Gallus gallus | 6 | assay format | Scientific Literature | ||
| 18. | ALA1942330 | B | Inhibition of human recombinant N-terminus His6-tagged AKR1B1 expressed in Escherichia coli BL21 DE3 assessed as pyridine-3-aldehyde reduction by spectrometric analysis | Homo sapiens | 24 | assay format | Scientific Literature | ||
| 19. | ALA1942331 | B | Inhibition of human recombinant N-terminus His6-tagged AKR1B10 expressed in Escherichia coli BL21 DE3 assessed as pyridine-3-aldehyde reduction by spectrometric analysis | Homo sapiens | 24 | assay format | Scientific Literature | ||
| 20. | ALA978379 | F | Antimutagenic activity in Salmonella Typhimurium TA100 assessed as inhibition of ethyl methanesulfonate-induced mutation at 3.9 uM treated for 30 mins and measured after 2 days by modified Ames test | Salmonella enterica subsp. enterica serovar Typhimurium | 7 | organism-based format | Scientific Literature |
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