# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA985385 | B | Displacement of fluorescein labeled BAD peptide from Bcl-XL by fluorescence polarization assay | 19 | ALA1142517 | single protein format | Scientific Literature | ||
2. | ALA985386 | B | Displacement of fluorescein labeled Bax peptide from Bcl2 by fluorescence polarization assay | 19 | ALA1142517 | single protein format | Scientific Literature | ||
3. | ALA985387 | F | Cytotoxicity against IL3-dependent mouse FL5.12 cells overexpressing human Bcl2 assessed as cell viability after 24 hrs by MTS assay in absence of serum | Mus musculus | 17 | ALA1142517 | cell-based format | Scientific Literature | |
4. | ALA985388 | F | Cytotoxicity against IL3-dependent mouse FL5.12 cells overexpressing human Bcl-XL assessed as cell viability after 24 hrs by MTS assay in absence of serum | Mus musculus | 16 | ALA1142517 | cell-based format | Scientific Literature | |
5. | ALA985389 | F | Cytotoxicity against human NCI-H146 cells assessed as cell viability after 48 hrs in presence of 10% human serum | Homo sapiens | 19 | ALA1142517 | cell-based format | Scientific Literature | |
6. | ALA985391 | A | AUC in Sprague-Dawley rat at 5 mg/kg, po | Rattus norvegicus | 14 | ALA1142517 | organism-based format | Scientific Literature | |
7. | ALA985392 | A | Oral bioavailability in Sprague-Dawley rat at 5 mg/kg | Rattus norvegicus | 5 | ALA1142517 | organism-based format | Scientific Literature | |
8. | ALA985393 | F | Ratio of AUC for Sprague-Dawley rat at 5 mg/kg, po to EC50 for human NCI-H146 cells in presence of 10% human serum | 14 | ALA1142517 | organism-based format | Scientific Literature | ||
9. | ALA985394 | A | AUC in CD1 mouse at 50 mg/kg, po | Mus musculus | 2 | ALA1142517 | organism-based format | Scientific Literature | |
10. | ALA985395 | A | AUC in Beagle dog at 2.5 mg/kg, iv or po | Canis lupus familiaris | 2 | ALA1142517 | organism-based format | Scientific Literature | |
11. | ALA985396 | A | AUC in cynomolgus monkey at 2.5 mg/kg, po | Macaca fascicularis | 2 | ALA1142517 | organism-based format | Scientific Literature | |
12. | ALA985397 | A | Oral elimination half life in Sprague-Dawley rat | Rattus norvegicus | 1 | ALA1142517 | organism-based format | Scientific Literature | |
13. | ALA985398 | A | Oral elimination half life in CD1 mouse | Mus musculus | 1 | ALA1142517 | organism-based format | Scientific Literature | |
14. | ALA985399 | A | Oral elimination half life in Beagle dog | Canis lupus familiaris | 1 | ALA1142517 | organism-based format | Scientific Literature | |
15. | ALA985400 | A | Oral elimination half life in cynomolgus monkey | Macaca fascicularis | 1 | ALA1142517 | organism-based format | Scientific Literature | |
16. | ALA985401 | A | Oral bioavailability in CD1 mouse | Mus musculus | 1 | ALA1142517 | organism-based format | Scientific Literature | |
17. | ALA985402 | A | Oral bioavailability in Beagle dog | Canis lupus familiaris | 1 | ALA1142517 | organism-based format | Scientific Literature | |
18. | ALA985403 | A | Oral bioavailability in cynomolgus monkey | Macaca fascicularis | 1 | ALA1142517 | organism-based format | Scientific Literature | |
19. | ALA985404 | F | Antitumor activity against human NCI-H146 cells xenografted C.B-17 SCID-bg mouse assessed as inhibition of tumor growth at 100 mg/kg, po daily once for 21 days | Homo sapiens | 1 | ALA1142517 | organism-based format | Scientific Literature | |
20. | ALA990639 | A | Oral bioavailability in Sprague-Dawley rat | Rattus norvegicus | 1 | ALA1142517 | organism-based format | Scientific Literature |