# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA971698 | B | Inhibition of CDK2/Cyclin A by radiometric assay | 29 | single protein format | Scientific Literature | |||
2. | ALA971700 | B | Inhibition of CDK1/Cyclin B by radiometric assay | 7 | protein complex format | Scientific Literature | |||
3. | ALA971707 | F | Antiproliferative activity against human HCT116 cells assessed as cell viability after 72 hrs by alamar blue assay | Homo sapiens | 15 | cell-based format | Scientific Literature | ||
4. | ALA971708 | A | Plasma clearance in BALB/c mouse bearing human HCT116 cells xenografts at 0.2 mg/kg, iv | Mus musculus | 11 | organism-based format | Scientific Literature | ||
5. | ALA4151772 | F | Protection against cisplatin-induced cell death in neonatal mouse HEI-OC1 cells assessed as reduction in caspase-3/7 activity | Mus musculus | 53 | assay format | Scientific Literature | ||
6. | ALA4151773 | F | Protection against cisplatin-induced toxicity in P3 mouse cochlear explants assessed as increase in outer hair cell count incubated for 24 hrs by phalloidin staining based confocal microscopy | Mus musculus | 9 | tissue-based format | Scientific Literature | ||
7. | ALA4151776 | B | Inhibition of C-terminal His6-tagged human full length CDK2/N-terminal GST-tagged human full length Cyclin A using histone H1 and [gamma-32P]-ATP incubated for 30 mins by phosphorimage based assay | Homo sapiens | 19 | protein complex format | Scientific Literature | ||
8. | ALA4151777 | F | Protection against cisplatin-induced toxicity in P3 mouse cochlear explants assessed as increase in outer hair cell count at 150 nM incubated for 24 hrs by phalloidin staining based confocal microscopy | Mus musculus | 4 | tissue-based format | Scientific Literature | ||
9. | ALA4151778 | T | Toxicity in adult FVB mouse at 2 to 50 uM dosed to each left ear by transtympanic injection after 15 days | Mus musculus | 2 | organism-based format | Scientific Literature | ||
10. | ALA4151779 | F | Protection against cisplatin-induced ototoxicity in adult FVB mouse assessed as reduction in auditory brainstem response threshold elevation by measuring ABR threshold shits at 16 kHz dosed at 50 uM administered to each left ear by transtympanic injection dosed 1 hr before cisplatin injection and measured after 15 days | Mus musculus | 1 | organism-based format | Scientific Literature | ||
11. | ALA4151780 | F | Protection against cisplatin-induced ototoxicity in adult FVB mouse assessed as reduction in auditory brainstem response threshold elevation by measuring ABR threshold shits at 32 kHz dosed at 50 uM administered to each left ear by transtympanic injection dosed 1 hr before cisplatin injection and measured after 15 days | Mus musculus | 2 | organism-based format | Scientific Literature | ||
12. | ALA4151781 | F | Protection against cisplatin-induced ototoxicity in adult FVB mouse assessed as reduction in outer hair cell loss in middle basal turn at 32 kHz dosed at 50 uM administered to each left ear by transtympanic injection dosed 1 hr before cisplatin injection and measured after 15 days | Mus musculus | 2 | organism-based format | Scientific Literature | ||
13. | ALA4151783 | B | Inhibition of human full length GSK3alpha expressed in bacterial expression system at 1 uM | Homo sapiens | 4 | assay format | Scientific Literature | ||
14. | ALA4151784 | B | Inhibition of human full length GSK3beta expressed in mammalian expression system at 1 uM | Homo sapiens | 4 | assay format | Scientific Literature | ||
15. | ALA4151785 | B | Inhibition of human full length CDK2 expressed in bacterial expression system at 1 uM | Homo sapiens | 4 | assay format | Scientific Literature | ||
16. | ALA4151786 | B | Inhibition of human full length CDK3 expressed in bacterial expression system at 1 uM | Homo sapiens | 4 | assay format | Scientific Literature | ||
17. | ALA4151787 | B | Inhibition of human full length CDK7 expressed in mammalian expression system at 1 uM | Homo sapiens | 4 | assay format | Scientific Literature | ||
18. | ALA4151788 | A | Permeability at 10 uM by PAMPA method | 2 | assay format | Scientific Literature | |||
19. | ALA4151789 | P | Solubility of the compound in citrate phosphate buffered saline incubated for 18 hrs by UV spectroscopy | 2 | small-molecule physicochemical format | Scientific Literature |