# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA985406 | B | Displacement of fluorescently tagged SM5F from human cIAP-2 BIR3 expressed in Escherichia coli BL21 cells by fluorescence polarization assay | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
2. | ALA985413 | F | Growth inhibition of human MDA-MB-231 cells after 4 days by WST8 assay | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
3. | ALA1025776 | B | Displacement of fluorescently tagged SM5F from human XIAP BIR3 expressed in Escherichia coli BL21 cells by fluorescence polarization assay | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
4. | ALA1025777 | B | Displacement of fluorescently tagged SM5F from human cIAP-1 BIR3 expressed in Escherichia coli BL21 cells by fluorescence polarization assay | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
5. | ALA2160283 | B | Binding affinity to BIR2-BIR3 domain of XIAP by fluorescence polarization assay | 12 | single protein format | Scientific Literature | |||
6. | ALA2160284 | B | Binding affinity to BIR2 domain of XIAP by fluorescence polarization assay | 4 | single protein format | Scientific Literature | |||
7. | ALA2160285 | B | Binding affinity to BIR3 domain of XIAP by fluorescence polarization assay | 12 | single protein format | Scientific Literature | |||
8. | ALA2160288 | B | Binding affinity to BIR3 domain of cIAP1 by fluorescence polarization assay | 12 | single protein format | Scientific Literature | |||
9. | ALA2160289 | B | Binding affinity to BIR3 domain of cIAP2 by fluorescence polarization assay | 12 | single protein format | Scientific Literature | |||
10. | ALA2160290 | F | Antagonist activity at XIAP linker BIR2-BIR3 domain assessed as induction of caspase-9 activity using Z-LEHD as substrate preincubated for 15 mins measured after 1 hr by luminescence analysis | 11 | assay format | Scientific Literature | |||
11. | ALA2160291 | F | Antagonist activity at XIAP linker BIR2-BIR3 domain assessed as induction of caspase-3 activity using Ac-DEVD-AFC as substrate preincubated for 15 mins measured after 1 hr by luminescence analysis | 11 | assay format | Scientific Literature | |||
12. | ALA2160292 | F | Growth inhibition of human MDA-MB-231 cells after 4 days by WST8 assay | Homo sapiens | 10 | cell-based format | Scientific Literature | ||
13. | ALA2160293 | F | Growth inhibition of human SKOV3 cells after 4 days by WST8 assay | Homo sapiens | 10 | cell-based format | Scientific Literature | ||
14. | ALA2160296 | B | Induction of cIAP1 protein degradation in human MDA-MB-231 cells at 10 nM after 24 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
15. | ALA2160297 | B | Induction of cIAP2 protein degradation in human MDA-MB-231 cells after 24 hrs by Western blot analysis | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
16. | ALA2160299 | B | Induction of cIAP2 protein degradation in human MDA-MB-231 cells at 10 to 30 nM after 24 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
17. | ALA2160305 | F | Induction of apoptosis in human MDA-MB-231 cells assessed as caspase 3 cleavage at 10 nM after 24 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
18. | ALA2160471 | F | Induction of apoptosis in human MDA-MB-231 cells assessed as caspase 8 cleavage at 10 nM after 24 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
19. | ALA2160472 | F | Induction of apoptosis in human MDA-MB-231 cells assessed as PARP cleavage at 300 nM after 24 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
20. | ALA2160474 | B | Induction of cIAP1 protein degradation in human SKOV3 cells at 10 nM after 24 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature |