| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA1036733 | F | Stimulation of human Vgamma9Vdelta2 T lymphocytes assessed as gamma delta expansion factor after 7 days | Homo sapiens | 9 | assay format | Scientific Literature | ||
| 2. | ALA1036745 | B | Inhibition of human FPP synthase expressed in Escherichia coli BL21 (DE3) | Homo sapiens | 7 | assay format | Scientific Literature | ||
| 3. | ALA4315899 | B | Inhibition of recombinant rat RabGGTase expressed in Escherichia coli using Rab7 as substrate and [3H]geranylgeranyl pyrophosphate after 20 mins by liquid scintillation analysis | Rattus norvegicus | 8 | assay format | Scientific Literature | ||
| 4. | ALA4315900 | B | Inhibition of recombinant rat GGtase-1 expressed in Escherichia coli using dansyl-GCVLL as substrate after 1.5 hrs by spectrofluorimetric analysis | Rattus norvegicus | 8 | assay format | Scientific Literature | ||
| 5. | ALA4315902 | B | Inhibition of recombinant rat FTase expressed in Escherichia coli using dansyl-GCVLS as substrate after 1.5 hrs by spectrofluorimetric analysis | Rattus norvegicus | 8 | assay format | Scientific Literature | ||
| 6. | ALA4315903 | B | Inhibition of FDPS (unknown origin) using [14C] IPP and GPP as substrate preincubated for 10 mins followed by substrate addition and measured after 30 min by liquid scintillation counting method | Homo sapiens | 8 | single protein format | Scientific Literature | ||
| 7. | ALA4315904 | B | Inhibition of GGDPS (unknown origin) using [14C] IPP and FPP as substrate preincubated for 10 mins followed by substrate addition and measured after 30 min by liquid scintillation counting method | Homo sapiens | 8 | single protein format | Scientific Literature | ||
| 8. | ALA4315905 | B | Selectivity ratio of IC50 for GGDPS (unknown origin) to IC50 for FDPS (unknown origin) | Homo sapiens | 4 | assay format | Scientific Literature | ||
| 9. | ALA4315906 | B | Inhibition of FDPS in human RPMI8226 cells assessed as minimum effective dose required to show unmodified Rap1a band after 48 hrs by immunoblot analysis | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 10. | ALA4315907 | B | Inhibition of FDPS in human RPMI8226 cells assessed as minimum effective dose causing increase in intracellular lambda chain level after 48 hrs by ELISA | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 11. | ALA4315908 | B | Inhibition of GGtase-2 in human cells assessed as minimum effective dose required for increase in intracellular lambda chain level after 48 hrs by ELISA | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 12. | ALA4315909 | B | Inhibition of GGtase-2 in human cells assessed as minimum effective dose causing => 20% decrease in Rab6 level after 48 hrs by immunoblot analysis | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 13. | ALA4315921 | B | Inhibition of FTase in human RPMI8226 cells assessed as disruption of H-ras farnesylation at 10 to 100 uM incubated for 48 hrs by immunoblot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 14. | ALA4315922 | B | Inhibition of GGtase-1 in human RPMI8226 cells assessed as disruption of Rap1a geranylgeranylation at 10 to 100 uM incubated for 48 hrs by immunoblot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 15. | ALA4315923 | B | Inhibition of GGtase-2 in human RPMI8226 cells assessed as accumulation of intracellular lambda light chain level at 10 to 100 uM after 48 hrs by immunoblot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 16. | ALA4315926 | B | Inhibition of FTase in human RPMI8226 cells assessed as disruption of H-ras farnesylation at 10 to 100 uM after 48 hrs in presence of lovastatin by immunoblot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 17. | ALA4315927 | B | Inhibition of GGtase-1 in human RPMI8226 cells assessed as disruption of Rap1a geranylgeranylation at 10 to 100 uM after 48 hrs in presence lovastatin by immunoblot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature |
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