# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA1038283 | Functional | Antagonist activity at human mGluR1 receptor expressed in CHO cell membranes assessed as inhibition of L-glutamate-induced calcium mobilization by FLIPR | Homo sapiens | 21 | ALA1155999 | cell-based format | Scientific Literature | |
2. | ALA1038284 | Functional | Antagonist activity at human mGluR5 receptor expressed in CHO cell membranes assessed as inhibition of L-glutamate-induced calcium mobilization by FLIPR | Homo sapiens | 5 | ALA1155999 | cell-based format | Scientific Literature | |
3. | ALA1038285 | Physicochemical | Octanol to water distribution coefficient, log D at pH 7.4 | 5 | ALA1155999 | small-molecule physicochemical format | Scientific Literature | ||
4. | ALA1038286 | ADME | Oral bioavailability in rat at 3 mg/kg | Rattus norvegicus | 5 | ALA1155999 | organism-based format | Scientific Literature | |
5. | ALA1038287 | ADME | Half life in rat at 3 mg/kg, po and 1 mg/kg, iv | Rattus norvegicus | 5 | ALA1155999 | organism-based format | Scientific Literature | |
6. | ALA1038288 | ADME | Plasma clearance in rat at 3 mg/kg, po and 1 mg/kg, iv | Rattus norvegicus | 5 | ALA1155999 | organism-based format | Scientific Literature | |
7. | ALA1032405 | Physicochemical | Octanol-water partition coefficient, log D at pH 7.4 by shake flask method | 16 | ALA1142531 | small-molecule physicochemical format | Scientific Literature | ||
8. | ALA1032406 | Functional | Antagonist activity at human mGluR1 expressed in CHO cells assessed as calcium flux by FLIPR assay | Homo sapiens | 16 | ALA1142531 | cell-based format | Scientific Literature | |
9. | ALA1032407 | Functional | Antagonist activity at mouse mGluR1 expressed in CHO cells assessed as calcium flux by FLIPR assay | Mus musculus | 16 | ALA1142531 | cell-based format | Scientific Literature | |
10. | ALA1032408 | Functional | Antagonist activity at human mGluR5 expressed in CHO cells assessed as calcium flux by FLIPR assay | Homo sapiens | 16 | ALA1142531 | cell-based format | Scientific Literature | |
11. | ALA1032409 | Binding | Selectivity for human mGluR1 over human mGluR5 | Homo sapiens | 1 | ALA1142531 | assay format | Scientific Literature | |
12. | ALA1032410 | Binding | Selectivity for mouse mGluR1 over human mGluR5 | 1 | ALA1142531 | assay format | Scientific Literature | ||
13. | ALA1032411 | Functional | Activity at human mGluR2 expressed in CHO cells at 10 uM by [35S]GTPgammaS binding assay | Homo sapiens | 1 | ALA1142531 | cell-based format | Scientific Literature | |
14. | ALA1032412 | Functional | Activity at human mGluR4 expressed in CHO cells at 10 uM by [35S]GTPgammaS binding assay | Homo sapiens | 1 | ALA1142531 | cell-based format | Scientific Literature | |
15. | ALA1032413 | Functional | Activity at human mGluR6 expressed in CHO cells at 10 uM by [35S]GTPgammaS binding assay | Homo sapiens | 1 | ALA1142531 | cell-based format | Scientific Literature | |
16. | ALA1032414 | Functional | Activity at human mGluR7 expressed in CHO cells at 10 uM by [35S]GTPgammaS binding assay | Homo sapiens | 1 | ALA1142531 | cell-based format | Scientific Literature | |
17. | ALA1032415 | Functional | Activity at human mGluR8 expressed in CHO-K1 cells at 10 uM by [35S]GTPgammaS binding assay | Homo sapiens | 1 | ALA1142531 | cell-based format | Scientific Literature | |
18. | ALA1032416 | Binding | Inhibition of AMPA receptor | 1 | ALA1142531 | assay format | Scientific Literature | ||
19. | ALA1032417 | Binding | Inhibition of NMDA receptor | 1 | ALA1142531 | assay format | Scientific Literature | ||
20. | ALA1032418 | Binding | Inhibition of kainate receptor | 1 | ALA1142531 | assay format | Scientific Literature |