| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA993399 | F | Antiviral activity against HIV1 in human 293T cells assessed as inhibition of viral replication after 48 hrs by multinuclear activation of galactosidase indicator assay | Human immunodeficiency virus 1 | 16 | organism-based format | Scientific Literature | ||
| 2. | ALA993400 | B | Binding affinity to HIV1 heptad repeat 1 peptide N36 assessed as melting temperature of drug-HR1 peptide complex | Human immunodeficiency virus 1 | 8 | assay format | Scientific Literature | ||
| 3. | ALA1049455 | B | Inhibition of Feline immunodeficiency virus Petaluma envelope glycoprotein gp40 assessed as inhibition of HR1-HR2 interaction after 1.5 hrs by ELISA | Feline immunodeficiency virus | 12 | assay format | Scientific Literature | ||
| 4. | ALA2034216 | B | Inhibition of HIV1 envelope glycoprotein 41-mediated membrane fusion between virus-transfected human HL2/3 cells and human TZM-bl cells after 6 hrs by luciferase reporter assay | Human immunodeficiency virus 1 | 25 | cell-based format | Scientific Literature | ||
| 5. | ALA2034217 | B | Inhibition of HIV1 envelope glycoprotein 41 infected in human HOS cells expressing CD4 assessed as inhibition of viral entry by luciferase reporter assay | Human immunodeficiency virus 1 | 1 | cell-based format | Scientific Literature | ||
| 6. | ALA3602695 | B | Inhibition of HIV-1 HXB2 gp41 N-terminal heptad repeat-mediated fusion between infected HL2/3 cells to target TZM-bl cells after 6 hrs by luciferase reporter gene assay | Human immunodeficiency virus 1 | 11 | cell-based format | Scientific Literature | ||
| 7. | ALA3602696 | F | Antiviral activity against HIV1 NL4-3 pseudovirus infected in human TZM-bl cells assessed as inhibition of viral entry into cells after 48 hrs by single-cycle infection assay | Human immunodeficiency virus 1 | 11 | organism-based format | Scientific Literature | ||
| 8. | ALA3602697 | F | Antiviral activity against wild type HIV1 NL4-3 infected in human TZM-bl cells assessed as inhibition of viral replication after 2 days by luciferase reporter gene assay | Human immunodeficiency virus 1 | 9 | organism-based format | Scientific Literature | ||
| 9. | ALA3602918 | B | Binding affinity to HIV-1 HXB2 gp41 N-terminal heptad repeat assessed as thermostability of compound at 10 uM after 30 mins by CD spectroscopic analysis | Human immunodeficiency virus 1 | 6 | single protein format | Scientific Literature | ||
| 10. | ALA4022548 | B | Inhibition of HIV1 gp41-induced cell-cell fusion between viral protein expressing human HL2/3 cells and TZM-bl target cells at 1 uM preincubated with cells followed by co-incubation for 6 hrs by luciferase reporter gene assay | Human immunodeficiency virus 1 | 1 | assay format | Scientific Literature | ||
| 11. | ALA4022550 | A | Cytotoxicity against human HL2/3 cells assessed as decrease in cell viability at 1 uM after 6 hrs | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 12. | ALA4022552 | A | Cytotoxicity against human TZM-bl cells assessed as decrease in cell viability at 1 uM after 6 hrs | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 13. | ALA4337644 | B | Binding affinity to HIV1 GP41 using GP41 NHR derived N36 peptide assessed as formation of secondary structure at 10 uM incubated for 30 mins by CD spectroscopy | Human immunodeficiency virus 1 | 4 | single protein format | Scientific Literature |
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