# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA995077 | B | Inhibition of Cryptosporidium hominis dihydrofolate reductase expressed in Escherichia coli by spectrophotometry | Cryptosporidium hominis | 11 | ALA1142493 | assay format | Scientific Literature | |
2. | ALA995078 | B | Inhibition of human dihydrofolate reductase by spectrophotometry | Homo sapiens | 11 | ALA1142493 | single protein format | Scientific Literature | |
3. | ALA995079 | B | Selectivity ratio of IC50 for Cryptosporidium hominis dihydrofolate reductase to IC50 for human dihydrofolate reductase | 11 | ALA1142493 | assay format | Scientific Literature | ||
4. | ALA1044821 | B | Inhibition of Candida albicans DHFR expressed in Escherichia coli BL21 (DE3) assessed as rate of NADPH consumption using dihydrofolate as substrate | Candida albicans | 82 | ALA1154109 | assay format | Scientific Literature | |
5. | ALA1044822 | B | Inhibition of human DHFR assessed as rate of NADPH consumption using dihydrofolate as substrate | Homo sapiens | 36 | ALA1154109 | single protein format | Scientific Literature | |
6. | ALA1044823 | B | Selectivity index, ratio of IC50 for human DHFR to IC50 for Candida albicans DHFR | 36 | ALA1154109 | assay format | Scientific Literature | ||
7. | ALA1044824 | F | Antifungal activity against Candida albicans by alamar blue assay | Candida albicans | 35 | ALA1154109 | organism-based format | Scientific Literature | |
8. | ALA1044825 | A | Cytotoxicity against human MCF10A cells after 4 hrs by alamar blue assay | Homo sapiens | 35 | ALA1154109 | cell-based format | Scientific Literature | |
9. | ALA1272639 | B | Inhibition of wild type Bacillus anthracis recombinant DHFR | Bacillus anthracis | 18 | ALA1268925 | single protein format | Scientific Literature | |
10. | ALA1272640 | B | Inhibition of Bacillus anthracis recombinant DHFR F96I mutant | Bacillus anthracis | 18 | ALA1268925 | assay format | Scientific Literature | |
11. | ALA1272641 | B | Selectivity ratio of Ki for wild type Bacillus anthracis recombinant DHFR to Ki for Bacillus anthracis recombinant DHFR F96I mutant | Bacillus anthracis | 18 | ALA1268925 | assay format | Scientific Literature | |
12. | ALA1272642 | B | Inhibition of Bacillus anthracis recombinant DHFR Y102F mutant | Bacillus anthracis | 18 | ALA1268925 | assay format | Scientific Literature | |
13. | ALA1272643 | B | Selectivity ratio of Ki for wild type Bacillus anthracis recombinant DHFR to Ki for Bacillus anthracis recombinant DHFR Y102F mutant | Bacillus anthracis | 18 | ALA1268925 | assay format | Scientific Literature | |
14. | ALA3227825 | B | Inhibition of methicillin-resistant Staphylococcus aureus DHFR | Staphylococcus aureus | 4 | ALA3217444 | single protein format | Scientific Literature | |
15. | ALA3227826 | B | Inhibition of methicillin-resistant Staphylococcus aureus DHFR F98Y mutant | Staphylococcus aureus | 4 | ALA3217444 | assay format | Scientific Literature | |
16. | ALA3227827 | F | Antibacterial activity against methicillin-resistant Staphylococcus aureus | Staphylococcus aureus | 4 | ALA3217444 | organism-based format | Scientific Literature | |
17. | ALA3226052 | B | Inhibition of methicillin-resistant Staphylococcus aureus DHFR F98Y/H30N double mutant | Staphylococcus aureus | 1 | ALA3217444 | assay format | Scientific Literature | |
18. | ALA3239990 | B | Inhibition of Candida glabrata DHFR using dihydrofolate as substrate preincubated for 5 mins followed by substrate addition in presence of NADPH | Nakaseomyces glabratus | 18 | ALA3232887 | assay format | Scientific Literature | |
19. | ALA3239991 | B | Inhibition of Candida albicans DHFR using dihydrofolate as substrate preincubated for 5 mins followed by substrate addition in presence of NADPH | Candida albicans | 18 | ALA3232887 | single protein format | Scientific Literature | |
20. | ALA3239993 | F | Antifungal activity against Candida glabrata SC5314 after 24 hrs by Alamar Blue assay | Nakaseomyces glabratus | 19 | ALA3232887 | organism-based format | Scientific Literature |