| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA995077 | B | Inhibition of Cryptosporidium hominis dihydrofolate reductase expressed in Escherichia coli by spectrophotometry | Cryptosporidium hominis | 11 | assay format | Scientific Literature | ||
| 2. | ALA995078 | B | Inhibition of human dihydrofolate reductase by spectrophotometry | Homo sapiens | 11 | single protein format | Scientific Literature | ||
| 3. | ALA995079 | B | Selectivity ratio of IC50 for Cryptosporidium hominis dihydrofolate reductase to IC50 for human dihydrofolate reductase | 11 | assay format | Scientific Literature | |||
| 4. | ALA1044821 | B | Inhibition of Candida albicans DHFR expressed in Escherichia coli BL21 (DE3) assessed as rate of NADPH consumption using dihydrofolate as substrate | Candida albicans | 82 | assay format | Scientific Literature | ||
| 5. | ALA1044822 | B | Inhibition of human DHFR assessed as rate of NADPH consumption using dihydrofolate as substrate | Homo sapiens | 36 | single protein format | Scientific Literature | ||
| 6. | ALA1044823 | B | Selectivity index, ratio of IC50 for human DHFR to IC50 for Candida albicans DHFR | 36 | assay format | Scientific Literature | |||
| 7. | ALA1044824 | F | Antifungal activity against Candida albicans by alamar blue assay | Candida albicans | 35 | organism-based format | Scientific Literature | ||
| 8. | ALA1044825 | A | Cytotoxicity against human MCF10A cells after 4 hrs by alamar blue assay | Homo sapiens | 35 | cell-based format | Scientific Literature | ||
| 9. | ALA1272639 | B | Inhibition of wild type Bacillus anthracis recombinant DHFR | Bacillus anthracis | 18 | single protein format | Scientific Literature | ||
| 10. | ALA1272640 | B | Inhibition of Bacillus anthracis recombinant DHFR F96I mutant | Bacillus anthracis | 18 | assay format | Scientific Literature | ||
| 11. | ALA1272641 | B | Selectivity ratio of Ki for wild type Bacillus anthracis recombinant DHFR to Ki for Bacillus anthracis recombinant DHFR F96I mutant | Bacillus anthracis | 18 | assay format | Scientific Literature | ||
| 12. | ALA1272642 | B | Inhibition of Bacillus anthracis recombinant DHFR Y102F mutant | Bacillus anthracis | 18 | assay format | Scientific Literature | ||
| 13. | ALA1272643 | B | Selectivity ratio of Ki for wild type Bacillus anthracis recombinant DHFR to Ki for Bacillus anthracis recombinant DHFR Y102F mutant | Bacillus anthracis | 18 | assay format | Scientific Literature | ||
| 14. | ALA3239990 | B | Inhibition of Candida glabrata DHFR using dihydrofolate as substrate preincubated for 5 mins followed by substrate addition in presence of NADPH | Nakaseomyces glabratus | 18 | assay format | Scientific Literature | ||
| 15. | ALA3239991 | B | Inhibition of Candida albicans DHFR using dihydrofolate as substrate preincubated for 5 mins followed by substrate addition in presence of NADPH | Candida albicans | 18 | single protein format | Scientific Literature | ||
| 16. | ALA3239992 | B | Inhibition of human DHFR using dihydrofolate as substrate preincubated for 5 mins followed by substrate addition in presence of NADPH | Homo sapiens | 16 | single protein format | Scientific Literature | ||
| 17. | ALA3239993 | F | Antifungal activity against Candida glabrata SC5314 after 24 hrs by Alamar Blue assay | Nakaseomyces glabratus | 19 | organism-based format | Scientific Literature | ||
| 18. | ALA3239994 | F | Antifungal activity against Candida albicans NCCLS84 after 24 hrs by XTT assay | Candida albicans | 18 | organism-based format | Scientific Literature | ||
| 19. | ALA3239995 | A | Cytotoxicity against human MCF10 cells | Homo sapiens | 16 | cell-based format | Scientific Literature | ||
| 20. | ALA3239996 | B | Selectivity ratio of IC50 for human DHFR to IC50 for Candida glabrata DHFR | 16 | assay format | Scientific Literature |
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